{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:26Z","timestamp":1753870166272,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Coronavirus Disease 2019 (COVID\u201019), caused by the virus named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS\u2010CoV\u20102), is a global public health problem in which atypical findings other than the usual fever and respiratory symptoms render early diagnosis and treatment difficult. Cases with atypical clinical and laboratory presentations continue to pose a challenge in the treatment and control of the disease. This case report aims to share our follow\u2010up and treatment experience in a patient considered to have antithrombin III (ATIII) deficiency based on activated clotting time (ACT) levels unresponsive to heparin who was admitted to intensive care unit due to COVID\u201019\u2010induced cytokine storm associated with extreme D\u2010dimer elevation (&gt;65,000\u2009\u03bcg\/L).<\/jats:p>","DOI":"10.1002\/rcr2.1394","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T06:30:52Z","timestamp":1717137052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A <scp>COVID<\/scp>\u201019 case report with low <scp>ACT<\/scp>(activated clotting time) and high serum D\u2010dimer level: Antithrombin <scp>III<\/scp> deficiency?"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-2531","authenticated-orcid":false,"given":"Ay\u015fe","family":"\u015eahin Tutak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Ad\u0131yaman University School of Medicine  Ad\u0131yaman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","first-page":"S17","article-title":"Antithrombin substitution therapy","volume":"9","author":"Schinzel H","year":"1998","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"3","article-title":"Antithrombin: structure and function","volume":"28","author":"Pratt CW","year":"1991","journal-title":"Semin Hematol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.7.4367"},{"issue":"9","key":"e_1_2_7_5_1","first-page":"1088","article-title":"Antithrombin acts as a negative acute phase protein as established with studies on HepG2 cells and in baboons","volume":"78","author":"Niessen RWLM","year":"1997","journal-title":"Thrombosis Haemost"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200005000-00013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.047430"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201629"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-995821"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)61132-0"},{"issue":"1","key":"e_1_2_7_11_1","first-page":"15","article-title":"Prognostic value of antithrombin levels in COVID\u201019 patients and impact of fresh frozen plasma treatment: a retrospective study","volume":"38","author":"Anakl\u0131 \u0130","year":"2021","journal-title":"Turk J Haematol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02339-3"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.10.029"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c02971"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T09:32:22Z","timestamp":1719307942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,30]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/rcr2.1394"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1394","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2024,5,30]]},"assertion":[{"value":"2024-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01394"}}