{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:32:47Z","timestamp":1783780367657,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Granulocyte colony\u2010stimulating factor (G\u2010CSF)\u2010producing lung tumours are rare, with their imaging features and effective treatments remaining elusive. Similarly, mesenchymal\u2010epithelial transition (MET) exon 14 skipping mutations are also uncommon. Herein, we report a case of G\u2010CSF\u2010producing lung adenocarcinoma positive for a MET exon 14 skipping mutation, mimicking lung abscess. A 61\u2010year\u2010old man presented with cough and high fever. Contrast\u2010enhanced chest computed tomography revealed a mass with a cavity and internal fluid accumulation. The patient initially underwent diagnostic treatment for a lung abscess but was ultimately diagnosed with lung adenocarcinoma positive for a MET exon 14 skipping mutation. Following tepotinib therapy, the primary lesion shrank, and serum G\u2010CSF levels decreased, leading to a diagnosis of G\u2010CSF\u2010producing lung cancer. G\u2010CSF\u2010producing lung tumours can present imaging findings that mimic lung abscesses. Tepotinib therapy may be effective for patients with MET exon 14 skipping mutation, including those with G\u2010CSF\u2010producing lung cancer.<\/jats:p>","DOI":"10.1002\/rcr2.1419","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T09:24:38Z","timestamp":1719307478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mesenchymal\u2010epithelial transition factor exon 14 skipping mutation\u2010positive granulocyte colony\u2010stimulating factor\u2010producing lung adenocarcinoma mimicking lung abscess: A case report"],"prefix":"10.1002","volume":"12","author":[{"given":"Yuka","family":"Izumiya","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Japanese Red Cross Akita Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7000-6884","authenticated-orcid":false,"given":"Hidesato","family":"Odaka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Japanese Red Cross Akita Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Post Graduate Clinical Education Center Japanese Red Cross Akita Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Takita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Japanese Red Cross Akita Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Tokairin","sequence":"additional","affiliation":[{"name":"Department of Pathology Japanese Red Cross Akita Hospital  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S231257"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V49.5.845.845"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-021-01130-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-005-0335-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmr.2018.07.010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-008-0146-z"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004407"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T09:31:34Z","timestamp":1719307894000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/rcr2.1419"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1419","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01419"}}