{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:28Z","timestamp":1753870168559,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019890","name":"University of Miyazaki Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nintedanib has been demonstrated to inhibit the rate of forced vital capacity decline in patients with progressive fibrosing interstitial lung diseases (PF\u2010ILD) at a dose of 200 or 300\u2009mg\/day in the INBUILD trial. Although concomitant use of nintedanib with P\u2010glycoprotein inhibitors reportedly increases the plasma concentrations of the former, tacrolimus, a P\u2010glycoprotein inhibitor, is often used to treat connective tissue diseases\u2010related interstitial lung diseases. The optimal dose of nintedanib in combination with tacrolimus for the treatment of PF\u2010ILD with connective tissue disease is unknown. We herein present two patients with PF\u2010ILD with anti\u2010aminoacyl\u2010tRNA synthetase antibody\u2010positive dermatomyositis who were successfully treated with low\u2010dose nintedanib (&lt;200\u2009mg\/day) in combination with tacrolimus.<\/jats:p>","DOI":"10.1002\/rcr2.1428","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T10:30:35Z","timestamp":1720521035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment with low\u2010dose nintedanib and tacrolimus in patients with progressive fibrosing interstitial lung diseases with anti\u2010<scp>ARS<\/scp> antibody\u2010positive dermatomyositis"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1615-5088","authenticated-orcid":false,"given":"Takeshi","family":"Kawaguchi","sequence":"first","affiliation":[{"name":"Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohiro","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Umekita","sequence":"additional","affiliation":[{"name":"Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiga","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Division of Respirology, Rheumatology, Infectious Diseases, and Neurology, Department of Internal Medicine, Faculty of Medicine University of Miyazaki  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908681"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-019-00766-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02411-y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu166"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2016.05.012"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.1428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T02:56:55Z","timestamp":1721962615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.1428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/rcr2.1428"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.1428","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01428"}}