{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:34:38Z","timestamp":1784777678111,"version":"3.55.0"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Malignant pleural mesothelioma (MPM<\/jats:styled-content>) is a rare tumor with a poor prognosis. Although cisplatin plus pemetrexed is the standard chemotherapy for patients with unresectable MPM<\/jats:styled-content>, few agents are available for MPM<\/jats:styled-content> patients who do not tolerate pemetrexed. Here, we report the first case of an MPM<\/jats:styled-content> patient for whom the combination of nanoparticle albumin\u2010bound paclitaxel and carboplatin (nabPC<\/jats:styled-content>) repetitively achieved tumor regression. A 76\u2010year\u2010old man was diagnosed with epithelioid MPM<\/jats:styled-content>. One cycle of carboplatin plus pemetrexed and two cycles of gemcitabine were administered but failed to inhibit tumor progression. By contrast, four cycles of nabPC<\/jats:styled-content> resulted in a good response. Upon disease progression, four cycles of nabPC<\/jats:styled-content> were performed again and resulted in a modest response. In conclusion, based on the present case, nabPC<\/jats:styled-content> is a potential alternative chemotherapeutic agent for MPM<\/jats:styled-content>, especially for MPM<\/jats:styled-content> patients who do not tolerate pemetrexed.<\/jats:p>","DOI":"10.1002\/rcr2.145","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T14:30:02Z","timestamp":1452781802000},"page":"28-31","source":"Crossref","is-referenced-by-count":9,"title":["Repetitive responses to nanoparticle albumin\u2010bound paclitaxel and carboplatin in malignant pleural mesothelioma"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0736-3317","authenticated-orcid":false,"given":"Osamu","family":"Kanai","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine National Hospital Organization Kyoto Medical Center 1\u20101 Fukakusa\u2010Mukaihata\u2010Cho Fushimi\u2010Ku Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine National Hospital Organization Kyoto Medical Center 1\u20101 Fukakusa\u2010Mukaihata\u2010Cho Fushimi\u2010Ku Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine National Hospital Organization Kyoto Medical Center 1\u20101 Fukakusa\u2010Mukaihata\u2010Cho Fushimi\u2010Ku Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Mio","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine National Hospital Organization Kyoto Medical Center 1\u20101 Fukakusa\u2010Mukaihata\u2010Cho Fushimi\u2010Ku Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"National Comprehensive Cancer Network 2015.NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) Malignant Pleural Mesothelioma Version 2.2015."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026438215309"},{"key":"e_1_2_6_4_1","first-page":"1001","article-title":"A case of malignant peritoneal mesothelioma successfully treated with carboplatin and paclitaxel","volume":"33","author":"Ogura O","year":"2006","journal-title":"Gan to Kagaku Ryoho"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.5848"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2015.03.005"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.145","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:14:38Z","timestamp":1696688078000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,14]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/rcr2.145"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.145","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,14]]}}}