{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:09:15Z","timestamp":1774008555686,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T00:00:00Z","timestamp":1484179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>There is currently no effective treatment for acute exacerbation of idiopathic pulmonary fibrosis (<jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content>). We herein report the case of a patient with acute exacerbation of <jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content> which was treated with nintedanib, an intracellular inhibitor of tyrosine kinases, and showed improvement of the condition. An 84\u2010year\u2010old man with <jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content> was admitted to our hospital because of dry cough and worsening of dyspnoea within last 1\u2009month. He presented with hypoxemia, and chest high\u2010resolution computed tomography (<jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content>) revealed new, bilateral multifocal ground\u2010glass opacities superimposed on the background of lung fibrosis. After exclusion of alternative causes, acute exacerbation of <jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content> was diagnosed and we started treatment with nintedanib of 300\u2009mg\/day. This resulted in the gradual improvement of his condition and <jats:styled-content style=\"fixed-case\">HRCT<\/jats:styled-content> findings without administering antibiotics or corticosteroids. Serum Krebs von den Lungen\u20106 and surfactant protein D levels increased at acute exacerbation and subsequently decreased. This case suggests that nintedanib therapy may have possible benefits in acute exacerbation of <jats:styled-content style=\"fixed-case\">IPF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/rcr2.215","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T13:14:13Z","timestamp":1484313253000},"source":"Crossref","is-referenced-by-count":22,"title":["Treatment with nintedanib for acute exacerbation of idiopathic pulmonary fibrosis"],"prefix":"10.1002","volume":"5","author":[{"given":"Hiromi","family":"Tomioka","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Kobe City Medical Center West Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kobe City Medical Center West Hospital  Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402584"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.02.001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.168.1.8976924"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200308-1111OC"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.208223"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.08.032"}],"updated-by":[{"DOI":"10.1002\/rcr2.455","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000}}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:13:04Z","timestamp":1696518784000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,12]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/rcr2.215"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.215","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1002\/rcr2.455","asserted-by":"object"}]},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,12]]},"article-number":"e00215"}}