{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:29:38Z","timestamp":1783225778985,"version":"3.54.6"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,26]],"date-time":"2017-02-26T00:00:00Z","timestamp":1488067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>We describe a rare and interesting case of a 37\u2010year\u2010old man who presented with an intermittent fever, progressive cytopenia, and hepatosplenomegaly. Histopathological examination of a bone marrow smear revealed haemophagocytes and intracellular yeast\u2010like <jats:italic>Histoplasma capsulatum<\/jats:italic> (<jats:italic>H. capsulatum<\/jats:italic>); thus, we prolonged the blood culture duration to detect fungi, and <jats:italic>H. capsulatum<\/jats:italic> was detected in the peripheral blood. After the diagnosis of disseminated histoplasmosis, the patient was successfully treated with amphotericin B and symptomatic therapy. This is the first case in southwest China for which <jats:italic>H. capsulatum<\/jats:italic> was cultivated in peripheral blood, illustrating that the duration of specimen culture should be lengthened if a specific pathogen infection is suspected. Moreover, this case enriches our understanding of clinical manifestations of disseminated histoplasmosis.<\/jats:p>","DOI":"10.1002\/rcr2.220","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T03:52:44Z","timestamp":1488167564000},"source":"Crossref","is-referenced-by-count":20,"title":["Disseminated histoplasmosis: a rare clinical phenotype with difficult diagnosis"],"prefix":"10.1002","volume":"5","author":[{"given":"Xiao\u2010feng","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010li","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The Second People's Hospital  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2010yun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine West China Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,26]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"785","article-title":"Epidemiology of endemic systemic fungal infections in Latin America","volume":"49","author":"Colombo AL","year":"2011","journal-title":"Med. 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