{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:25:07Z","timestamp":1789579507544,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Diffuse panbronchiolitis (<jats:styled-content style=\"fixed-case\">DPB<\/jats:styled-content>) and asthma are obstructive airway diseases, the former being characterized by Th1\u2010type and the latter by Th2\u2010type airway inflammation. Differential diagnosis is often a problem, but coexistence has rarely been reported. A 76\u2010year\u2010old man with asthma was admitted to our hospital because of one\u2010month history of dyspnoea on exertion with bilateral diffuse granular shadows. He also had a history of chronic sinusitis. Auscultation of the lungs showed coarse crackles and wheezes. Laboratory data revealed an elevated total serum immunoglobulin <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> and a high titre of cold agglutinin. Bronchoscopic evaluations of the shadows revealed compatible pathological findings in both <jats:styled-content style=\"fixed-case\">DPB<\/jats:styled-content> and asthma. Low\u2010dose macrolide caused a prompt reduction of symptoms, along with improvements in radiographic findings and pulmonary functions, whereas the eosinophilic airway inflammation transiently worsened. When <jats:styled-content style=\"fixed-case\">DPB<\/jats:styled-content> and asthma coexist, the balance of Th1\/Th2 immune response may be reciprocally altered by therapeutic intervention.<\/jats:p>","DOI":"10.1002\/rcr2.232","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T12:40:59Z","timestamp":1491396059000},"source":"Crossref","is-referenced-by-count":4,"title":["Coexistence of diffuse panbronchiolitis and asthma: reciprocity of neutrophilic and eosinophilic inflammation"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1734-0031","authenticated-orcid":false,"given":"Kiyoshi","family":"Takeyama","sequence":"first","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Shimizu","sequence":"additional","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Ishii","sequence":"additional","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Hara","sequence":"additional","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuko","family":"Kondo","sequence":"additional","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tamaoki","sequence":"additional","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2015.30.6.823"},{"key":"e_1_2_4_3_1","first-page":"632","article-title":"Clinical effects of low\u2010dose long\u2010term erythromycin chemotherapy on diffuse panbronchiolitis","volume":"25","author":"Kudoh S","year":"1987","journal-title":"Nihon Kyobu Shikkan Gakkai Zasshi"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.09.018"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770901003759444"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00101705"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T17:00:20Z","timestamp":1696525220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,3]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/rcr2.232"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.232","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,3]]},"article-number":"e00232"}}