{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:52:43Z","timestamp":1770749563664,"version":"3.50.0"},"reference-count":5,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP16K09529"],"award-info":[{"award-number":["JP16K09529"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2017,7]]},"abstract":"A 59\u2010year\u2010old Japanese man diagnosed with interstitial lung disease associated with amyopathic dermatomyositis with anti\u2010melanoma differentiation\u2010associated gene 5 (MDA<\/jats:styled-content>\u20105) antibodies was treated with intravenous methyl prednisolone (PSL<\/jats:styled-content>) 1000\u2009mg, oral PSL<\/jats:styled-content> 1\u2009mg\/kg, and oral cyclosporin 200\u2009mg daily. His respiratory condition worsened after treatment with two times of intravenous cyclophosphamide and another steroid pulse therapy as well as PSL<\/jats:styled-content> and cyclosporin. Addition of mycophenolate mofetil (MMF<\/jats:styled-content>), 1.5\u2009g daily improved PaO2<\/jats:sub>\n<\/jats:styled-content>\/FiO2<\/jats:sub>\n<\/jats:styled-content> (PF<\/jats:styled-content>) ratio of the patient from 294 to 360 at 4 weeks and 416 at 15 weeks after addition of MMF<\/jats:styled-content>. We measured cytokine concentration in preserved serum taken at 11 and 7 weeks before addition of MMF<\/jats:styled-content> and at 4, 11, and 15 weeks after MMF<\/jats:styled-content> administration. Of the 28 cytokines evaluated, the concentrations of fibroblast growth factors\u20102 (FGF<\/jats:styled-content>\u20102), chemokine (C\u2010X3<\/jats:styled-content>\u2010C motif) ligand 1 (CX3CL1<\/jats:styled-content>), interleukin (IL<\/jats:styled-content>)\u20101ra, IL\u201017A<\/jats:styled-content>, inducible protein 10 (IP<\/jats:styled-content>\u201010), and monocyte chemotactic protein\u20101 (MCP<\/jats:styled-content>\u20101) decreased after addition of MMF<\/jats:styled-content>. These results suggest that MMF<\/jats:styled-content> may be beneficial to patients with interstitial lung disease by modification of the cytokine\/growth factor protein expression.<\/jats:p>","DOI":"10.1002\/rcr2.235","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T09:22:41Z","timestamp":1491902561000},"source":"Crossref","is-referenced-by-count":16,"title":["Cytokine profiles of amyopathic dermatomyositis with interstitial lung diseases treated with mycophenolate"],"prefix":"10.1002","volume":"5","author":[{"given":"Masachika","family":"Hayashi","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami","family":"Aoki","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuaki","family":"Asakawa","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Sakagami","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-8375","authenticated-orcid":false,"given":"Toshinori","family":"Takada","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine Niigata University Medical and Dental Hospital Niigata Japan"},{"name":"Uonuma Institute of Community Medicine Niigata University Medical and Dental Hospital Minami\u2010uonuma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21985"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121043"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3443-2"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2015.07.004"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2928-8"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T18:51:53Z","timestamp":1696531913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,11]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/rcr2.235"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.235","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,11]]},"article-number":"e00235"}}