{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:14:10Z","timestamp":1759515250526,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Hospital Organization's fiduciary funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Nivolumab improves overall survival rates of patients with advanced or recurrent non\u2010small\u2010cell lung cancer (<jats:styled-content style=\"fixed-case\">NSCLC<\/jats:styled-content>). Among immune\u2010related adverse events caused by nivolumab, interstitial lung disease (<jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>) is a clinically serious and potentially life\u2010threatening toxicity, for which appropriate treatment is needed immediately. However, <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> is sometimes difficult to distinguish from invasive lung adenocarcinoma using only computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) findings. A 71\u2010year\u2010old man was diagnosed with advanced lung adenocarcinoma. The patient developed dyspnoea after eight cycles of nivolumab, when chest <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> indicated <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> classified with a cryptogenic organizing pneumonia (<jats:styled-content style=\"fixed-case\">COP<\/jats:styled-content>) pattern. Although immunosuppressive therapies improved the <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> findings temporarily, dyspnoea was re\u2010exacerbated 2 months later. The <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> findings helped in making the diagnosis of a combination of <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> and invasive lung cancer, confirmed by a transbronchial lung biopsy. In conclusion, nivolumab\u2010related <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> and cancer invasion may concur and aggressive biopsy should be considered if nivolumab\u2010related <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> is refractory to immunosuppressive therapy.<\/jats:p>","DOI":"10.1002\/rcr2.257","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T13:18:36Z","timestamp":1502457516000},"source":"Crossref","is-referenced-by-count":11,"title":["Concurrence of nivolumab\u2010induced interstitial lung disease and cancer invasion"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0736-3317","authenticated-orcid":false,"given":"Osamu","family":"Kanai","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Fujita","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misato","family":"Okamura","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Mio","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine National Hospital Organization Kyoto Medical Center  Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,11]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507643"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.11.016"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-211771"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0267"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyw053"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T23:07:42Z","timestamp":1696460862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/rcr2.257"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.257","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2017,8,11]]},"article-number":"e00257"}}