{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:33:55Z","timestamp":1768887235342,"version":"3.49.0"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T00:00:00Z","timestamp":1507161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) remains a poorly understood clinical entity. It is currently classified as a premalignant condition by the World Health Organization (WHO). Symptoms are similar to those associated with obstructive lung disease, including breathlessness and cough. The presentation is often initially ascribed to other diseases such as asthma or chronic obstructive pulmonary disease. Here, we present what we believe is the first described case of DIPNECH diagnosed by transbronchoscopic cryoprobe biopsy. The patient presented with chronic cough, dyspnoea, pulmonary function tests consistent with obstruction, and a computed tomography (CT) scan of chest with multiple nodules. The patient went on to have transbronchoscopic cryoprobe biopsies of the lung, which confirmed the diagnosis of DIPNECH.<\/jats:p>","DOI":"10.1002\/rcr2.275","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T14:42:39Z","timestamp":1507214559000},"source":"Crossref","is-referenced-by-count":4,"title":["Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia diagnosed by tranbronchoscopic cryoprobe biopsy technique"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-8282","authenticated-orcid":false,"given":"Ravi","family":"Patel","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine James A. Haley Veteran\u2019s Hospital  Tampa FL USA"},{"name":"Division of Pulmonary and Critical Care Medicine Morsani College of Medicine at the University of South Florida  Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Collazo\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine James A. Haley Veteran\u2019s Hospital  Tampa FL USA"},{"name":"Division of Pulmonary and Critical Care Medicine Morsani College of Medicine at the University of South Florida  Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Andrews","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine James A. Haley Veteran\u2019s Hospital  Tampa FL USA"},{"name":"Division of Pulmonary and Critical Care Medicine Morsani College of Medicine at the University of South Florida  Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pathology James A. Haley Veteran\u2019s Hospital  Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Rumbak","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine James A. Haley Veteran\u2019s Hospital  Tampa FL USA"},{"name":"Division of Pulmonary and Critical Care Medicine Morsani College of Medicine at the University of South Florida  Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pathology Mayo Clinic  Scottsdale AZ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-0711"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201010-1685PP"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-6-53"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12309"},{"issue":"4","key":"e_1_2_4_6_1","first-page":"1","article-title":"Transbronchial lung cryobiopsy (TBLC) at a tertiary Referral hospital: a two year experience","volume":"1","author":"Dalvi P","year":"2016","journal-title":"Pulm. Crit. Care Med."}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T23:07:40Z","timestamp":1696460860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,5]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/rcr2.275"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.275","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,5]]},"article-number":"e0275"}}