{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:37Z","timestamp":1753870177852,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>A 65\u2010year\u2010old man was diagnosed with granulomatosis with polyangiitis (GPA) at the age of 47, when cytoplasmic anti\u2010neutrophil cytoplasmic antibody (C\u2010ANCA) serology was positive, and he had multiple nodular shadows in both lungs. He had been treated with prednisolone, cyclophosphamide (CPA) and plasma exchange. At the age of 64, a nodular shadow was newly detected in the right lower lung field and serum tumour marker increased. Subsequent positron emission tomography\/computed tomography scan demonstrated accumulations of fluorodexyglucose (FDG) in the same area, mediastinum lymph nodes, thoracic wall, right iliac bone, and right retroperitoneum. The diagnosis of squamous cell lung cancer cT2bN2M1b Stage4 was made with endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA). There are no reports of cases that lung cancer has developed with GPA during the long\u2010term treatment with CPA. We suggest that in such patients, the differential diagnosis should include not only the relapse of GPA, but also the rare possibility of development of carcinomas.<\/jats:p>","DOI":"10.1002\/rcr2.284","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T07:46:25Z","timestamp":1514101585000},"source":"Crossref","is-referenced-by-count":8,"title":["Lung cancer development in the patient with granulomatosis with polyangiitis during long term treatment with cyclophosphamide: first documented case"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3852-5449","authenticated-orcid":false,"given":"Midori","family":"Toriyama","sequence":"first","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etsuko","family":"Tagaya","sequence":"additional","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Tokyo Women's Medical University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Kondo","sequence":"additional","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Tokyo Women's Medical University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tamaoki","sequence":"additional","affiliation":[{"name":"First Department of Medicine Tokyo Women's Medical University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-12-199512150-00005"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.97.4.906"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36156-6"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90490-6"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN107407"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T21:07:01Z","timestamp":1695935221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,22]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/rcr2.284"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.284","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2017,12,22]]},"article-number":"e00284"}}