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In this series, we present three cases of patients with features of both asthma and COPD in addition to peripheral blood eosinophilia. The novel implementation of personalized management of the individual based on this treatable trait (eosinophilia) resulted in significant benefits. These benefits included improvement in symptoms, lung function, and a marked decline in critical care admissions and exacerbation rates.<\/jats:p>","DOI":"10.1002\/rcr2.295","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T14:38:32Z","timestamp":1516286312000},"source":"Crossref","is-referenced-by-count":6,"title":["Eosinophilia as a treatable trait in three patients with asthma and COPD"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5164-9374","authenticated-orcid":false,"given":"James Michael","family":"Ramsahai","sequence":"first","affiliation":[{"name":"Hunter Medical Research Institute University of Newcastle  New Lambton NSW Australia"},{"name":"Division of Respirology, Cumming School of Medicine University of Calgary  Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie","family":"Simpson","sequence":"additional","affiliation":[{"name":"Hunter Medical Research Institute University of Newcastle  New Lambton NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wark","sequence":"additional","affiliation":[{"name":"Hunter Medical Research Institute University of Newcastle  New Lambton NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01359-2015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.09.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.06.007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00146306"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60988-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11679-5"},{"key":"e_1_2_6_8_1","first-page":"Cd005603","article-title":"Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults","author":"Petsky HL","year":"2007","journal-title":"The Cochrane Database of Systematic Reviews 18"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-15-37"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70187-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708208"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.6.9811041"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00367-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00436-2016"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61452-X"},{"key":"e_1_2_6_16_1","article-title":"After asthma: redefining airways diseases","author":"Pavord ID","year":"2017","journal-title":"Lancet"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2012-202646"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T01:13:49Z","timestamp":1695604429000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,18]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/rcr2.295"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.295","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,18]]},"article-number":"e00295"}}