{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:58:52Z","timestamp":1760043532704,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>Antineutrophil cytoplasmic antibody (ANCA)\u2010associated vasculitis (AAV) caused by methimazole (MMI) is known to be relatively rare; therefore, the optimal therapeutic approach for these cases remains to be established. A 59\u2010year\u2010old man who was treated with MMI for a diagnosis of Graves\u2019 disease was referred to our hospital because of progressive haemoptysis. The patient was diagnosed with diffuse alveolar haemorrhage (DAH) secondary to AAV based on increased inflammatory reactions with positive myeloperoxidase\u2010ANCA in the serum and the results of bronchoalveolar lavage fluid. MMI was suspected as the cause of the AAV; therefore, the administration of MMI was discontinued. Thereafter, the patient\u2019s symptoms as well as chest radiographic abnormalities completely resolved, in conjunction with normalization of the serum ANCA level. Our experience with this case suggests that DAH secondary to AAV caused by MMI may improve with discontinuation of the offending drug alone, with no other treatment.<\/jats:p>","DOI":"10.1002\/rcr2.315","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T14:40:50Z","timestamp":1525790450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Methimazole\u2010induced ANCA\u2010associated vasculitis with diffuse alveolar haemorrhage"],"prefix":"10.1002","volume":"6","author":[{"given":"Naoki","family":"Arai","sequence":"first","affiliation":[{"name":"National Hospital Organization Ibarakihigashi National Hospital  Naka\u2010gun Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-8274","authenticated-orcid":false,"given":"Kenji","family":"Nemoto","sequence":"additional","affiliation":[{"name":"National Hospital Organization Ibarakihigashi National Hospital  Naka\u2010gun Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Oh\u2010ishi","sequence":"additional","affiliation":[{"name":"National Hospital Organization Ibarakihigashi National Hospital  Naka\u2010gun Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizu","family":"Nonaka","sequence":"additional","affiliation":[{"name":"National Hospital Organization Ibarakihigashi National Hospital  Naka\u2010gun Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Hayashihara","sequence":"additional","affiliation":[{"name":"National Hospital Organization Ibarakihigashi National Hospital  Naka\u2010gun Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takefumi","family":"Saito","sequence":"additional","affiliation":[{"name":"National Hospital Organization Ibarakihigashi National Hospital  Naka\u2010gun Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2700"},{"key":"e_1_2_4_3_1","first-page":"209","article-title":"Methimazole\u2010induced antineutrophil cytoplasmic antibody\u2010associated diffuse alveolar haemorrhage in a Chinese woman with Graves\u2019 disease","volume":"15","author":"Lau EYF","year":"2009","journal-title":"Hong Kong Med. J."},{"key":"e_1_2_4_4_1","first-page":"772","article-title":"Methimazole\u2010induced pulmonary hemorrhage associated with antimyeloperoxidase\u2010antineutrophil cytoplasmic antibody: a case report","volume":"100","author":"Tsai MH","year":"2001","journal-title":"J. Formos. Med. Assoc."},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1998.tb01930.x"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34619"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:45:28Z","timestamp":1695473128000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,8]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/rcr2.315"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.315","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2018,5,8]]},"assertion":[{"value":"2018-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00315"}}