{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T09:37:08Z","timestamp":1771061828671,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>A 60\u2010year\u2010old female with severe bronchial asthma developed persistent dyspnoea and an abnormal lung shadow. High\u2010resolution computed tomography (HRCT) demonstrated patchy ground\u2010glass opacities and diffuse, small nodular shadows. Elevated percentages of eosinophils were observed in the blood and bronchoalveolar lavage fluid. These results collectively indicated that her asthma was accompanied by eosinophilic pneumonia and eosinophilic bronchiolitis. Although previous, rare case reports suggest that systemic steroid therapy is necessary and effective for the control of eosinophilic bronchiolitis, we chose to treat her with an anti\u2010interleukin 5 antibody, mepolizumab. Her asthma, eosinophilic pneumonia, and eosinophilic bronchiolitis each improved in response to mepolizumab as assessed from her symptoms, pulmonary function tests, and HRCT. Mepolizumab might be effective not only for asthma and eosinophilic pneumonia but also for eosinophilic bronchiolitis.<\/jats:p>","DOI":"10.1002\/rcr2.397","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T13:50:59Z","timestamp":1545141059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Anti\u2010interleukin 5 antibody is effective for not only severe asthma and eosinophilic pneumonia but also eosinophilic bronchiolitis"],"prefix":"10.1002","volume":"7","author":[{"given":"Fuminori","family":"Tomyo","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine and Allergology, Department of Medicine Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9632-7029","authenticated-orcid":false,"given":"Naoya","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Allergology, Department of Medicine Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Teikyo University Mizonokuchi Hospital  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nagase","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Allergology, Department of Medicine Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Allergology, Department of Medicine Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Ohta","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine and Allergology, Department of Medicine Teikyo University School of Medicine  Tokyo Japan"},{"name":"National Hospital Organization Tokyo National Hospital  Kiyose Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000050518"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.09-CR-0114"},{"key":"e_1_2_4_4_1","first-page":"99","article-title":"Eosinophilic bronchiolitis indicating eosinophilic airway disease with overexpression of carcinoembryonic antigen in sinus and bronchiole: case report","volume":"24","author":"Yanagitani N","year":"2010","journal-title":"J. Biol. Regul. Homeost. 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