{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:47Z","timestamp":1753870187356,"version":"3.41.2"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>A 46\u2010year\u2010old woman with severe skin sarcoidosis, mainly on the back of the trunk, persisting for &gt;15\u2009years, was followed up without systemic treatment. In 2014, she was started on minocycline monotherapy owing to worsening of the skin sarcoid lesions. Surprisingly, after approximately 1 year of the monotherapy, nearly all skin lesions resolved with only light residual scars, despite the poor efficacy of the monotherapy for pulmonary sarcoidosis. The patient's serum angiotensin\u2010converting enzyme levels also decreased to the normal range. The presence of <jats:styled-content style=\"fixed-case\"><jats:italic>Propionibacterium acnes<\/jats:italic><\/jats:styled-content> was confirmed when a retrospectively immunostained epithelioid granuloma, obtained from skin biopsy, demonstrated staining with monoclonal antibodies specific for <jats:italic>P. acnes<\/jats:italic>. Minocycline monotherapy, thus, appears to be a possible treatment modality for skin sarcoidosis.<\/jats:p>","DOI":"10.1002\/rcr2.413","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T15:12:56Z","timestamp":1552489976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Management of skin sarcoidosis with minocycline monotherapy"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2257-7658","authenticated-orcid":false,"given":"Shinichi","family":"Sasaki","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Urayasu Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3217-5118","authenticated-orcid":false,"given":"Motoyasu","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Urayasu Hospital  Chiba Japan"},{"name":"Department of Respiratory Medicine Juntendo University, Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Urayasu Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Namba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Urayasu Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Nagashima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University Urayasu Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Juntendo University, Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,13]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2013.01.001"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.1.69"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.80"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.5.705"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-8-15"},{"key":"e_1_2_4_7_1","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/archderm.1984.01650460048018","article-title":"Neutrophil chemotaxis in patients with acne receiving oral tetracycline therapy","volume":"120","author":"Esterly NB","year":"1984","journal-title":"Arch. 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