{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:12Z","timestamp":1753870152997,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T00:00:00Z","timestamp":1580860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Malignant pleural effusions usually manifest in the course of metastatic cancer disease. Primary pleural tumours are rare with mesothelioma being by far the most common. Primary squamous cell carcinoma of the pleura (PSCCP) is extremely rare. It is usually asymptomatic, until it invades the pleura presenting pain as the first symptom. Our knowledge about its treatment or prognosis is limited due to its rarity. We present the case of a 48\u2010year\u2010old man who presented with persistent right\u2010sided thoracic pain with chest computed tomography (CT) scan demonstrating a right\u2010sided pleural effusion and pleural mass invading the ribs. Ultrasound\u2010guided biopsy revealed a PSCCP. Positron emission tomography staging demonstrated metastatic lung and lymph node involvement precluding surgical therapy. We provide information about treatment, including immunotherapy as well as extended follow\u2010up course. Immunotherapy with nivolumab resulted in prolongation of survival with good quality of life.<\/jats:p>","DOI":"10.1002\/rcr2.516","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T09:59:00Z","timestamp":1580896740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary squamous cell carcinoma of the pleura treated with nivolumab"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3547-1665","authenticated-orcid":false,"given":"Ioanna","family":"Sigala","sequence":"first","affiliation":[{"name":"1st Department of Critical Care and Pulmonary Medicine Evaggelismos Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nektarios","family":"Alevizopoulos","sequence":"additional","affiliation":[{"name":"Department of Oncology Evaggelismos Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Elefteriou","sequence":"additional","affiliation":[{"name":"1st Department of Critical Care and Pulmonary Medicine Evaggelismos Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niki","family":"Gianniou","sequence":"additional","affiliation":[{"name":"1st Department of Critical Care and Pulmonary Medicine Evaggelismos Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Kalomenidis","sequence":"additional","affiliation":[{"name":"1st Department of Critical Care and Pulmonary Medicine Evaggelismos Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_4_2_1","DOI":"10.1186\/1749-8090-8-50"},{"doi-asserted-by":"publisher","key":"e_1_2_4_3_1","DOI":"10.1136\/thx.44.12.1053"},{"doi-asserted-by":"publisher","key":"e_1_2_4_4_1","DOI":"10.1016\/j.amjsurg.2009.05.004"},{"doi-asserted-by":"publisher","key":"e_1_2_4_5_1","DOI":"10.1111\/cyt.12498"},{"doi-asserted-by":"publisher","key":"e_1_2_4_6_1","DOI":"10.2147\/ITT.S125070"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T12:17:56Z","timestamp":1694089076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,5]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/rcr2.516"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.516","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2020,2,5]]},"assertion":[{"value":"2019-10-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00516"}}