{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T14:34:57Z","timestamp":1784385297966,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune checkpoint inhibitors (ICIs) have become pivotal in the treatment of lung cancer. An increasing number of immune\u2010related adverse events (irAEs) have been recognized with their use. To our knowledge, this is the first published case of sarcoid\u2010like pulmonary lymphadenopathy associated with durvalumab, a monoclonal antibody against programmed death ligand\u20101 (PD\u2010L1). A 76\u2010year\u2010old woman received adjuvant durvalumab for Stage IIA pT2aN1M0 (American Joint Committee on Cancer, Seventh edition) poorly differentiated lung adenocarcinoma. After three cycles, a sarcoid\u2010like granulomatous reaction was identified in mediastinal and hilar lymph nodes. Although the lymphadenopathy remained stable in size with the ongoing treatment, progressive intracranial metastases were identified after a further three cycles of durvalumab. Sarcoid\u2010like inflammation with the formation of non\u2010caseating granulomas in the absence of systemic sarcoidosis is an irAE which may mimic disease progression. Although a subset of patients who experience this reaction may have a favourable response to checkpoint inhibition, progression of disease may occur contemporaneously.<\/jats:p>","DOI":"10.1002\/rcr2.542","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T08:51:01Z","timestamp":1582620661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Durvalumab induced sarcoid\u2010like pulmonary lymphadenopathy"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4605-3891","authenticated-orcid":false,"given":"Emma","family":"Sanderson","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Austin Health  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari","family":"Wimaleswaran","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Austin Health  Melbourne VIC Australia"},{"name":"Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Senko","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Austin Health  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"White","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Melbourne VIC Australia"},{"name":"Department of Medical Oncology Austin Health  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine F.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Austin Health  Melbourne VIC Australia"},{"name":"Faculty of Medicine, Dentistry and Health Sciences University of Melbourne  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,25]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160221"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-019-01490-2"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2018-0035"},{"issue":"2","key":"e_1_2_4_5_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1513\/AnnalsATS.201611-863LE","article-title":"Sarcoidosis\u2010like granulomatous lung reaction associated with anti\u2013programmed death receptor\u20101 ligand therapy","volume":"14","author":"Balestra R","year":"2017","journal-title":"Ann. Am. Thorac. Soc."},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0323-0"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491599"},{"key":"e_1_2_4_8_1","first-page":"15","article-title":"Magnetic resonance imaging of neurosarcoidosis","volume":"1","author":"Ginat DT","year":"2011","journal-title":"J. Clin. 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