{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:16Z","timestamp":1753870156826,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the first case of autoimmune pulmonary alveolar proteinosis (PAP) associated with and preceding myelodysplastic syndrome. A 74\u2010year\u2010old female with a history of polymyalgia rheumatica presented with six months history of progressive exertional breathlessness. Examination revealed bilateral chest crackles and exertional desaturation. A diagnosis of autoimmune PAP was made based on the presence of autoantibodies to granulocyte\u2010macrophage colony\u2010stimulating factor and characteristic findings on chest computed tomography, bronchoalveolar lavage, and transbronchial biopsies. Bilateral whole lung lavage was performed with prompt improvement in symptoms. Fourteen months later, she presented with new breathlessness and was diagnosed with myelodysplasia on bone marrow biopsy. No recurrence of alveolar proteinosis was detected. This case highlights the importance of follow\u2010up and screening of patients with autoimmune PAP for haematological conditions.<\/jats:p>","DOI":"10.1002\/rcr2.569","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T02:24:38Z","timestamp":1588731878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Autoimmune pulmonary alveolar proteinosis prior to myelodysplastic syndrome"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-9830","authenticated-orcid":false,"given":"Chuan Tai","family":"Foo","sequence":"first","affiliation":[{"name":"Eastern Health  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Chhor","sequence":"additional","affiliation":[{"name":"Eastern Health  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Thien","sequence":"additional","affiliation":[{"name":"Eastern Health  Melbourne VIC Australia"},{"name":"Eastern Health Clinical School Monash University  Melbourne VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195806052582301"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30043-2"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092910"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2109105"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200708-1271OC"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.11.011"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0097"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.890218"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.4.504"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2011.08.018"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.56.6920"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1666-z"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203465"},{"key":"e_1_2_4_15_1","article-title":"Polymyalgia rheumatica and its association with cancer","volume":"2015","author":"Pfeifer EC","year":"2015","journal-title":"Rheumatology (Sunnyvale)"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1757-y"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2015.11.013"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2014.09.003"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00197710"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0978OC"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Frcr2.569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.569","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.569","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:23:11Z","timestamp":1693970591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/rcr2.569"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.569","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2020,5,5]]},"assertion":[{"value":"2020-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00569"}}