{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:16Z","timestamp":1753870156821,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An 82\u2010year\u2010old man was presented to our hospital due to epigastric and right hypochondrial pain 17\u2009weeks after the initiation of intravenous treatment with nivolumab for recurrent lung adenocarcinoma as multiple lung and sternal metastases. Urgent gastroscopy revealed macroscopic duodenitis such as severe erythema, oedema, black\u2010coloured erosions, and ulcers located throughout the second portion of the duodenum, which was confirmed by abdominal computed tomography as circumferential thickening of the duodenal wall. Those lesions were pathologically considered as non\u2010specific inflammation and spontaneously disappeared within a month, suggesting nivolumab\u2010induced immune\u2010related adverse events.<\/jats:p>","DOI":"10.1002\/rcr2.582","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T04:16:07Z","timestamp":1589256967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An extremely rare case of nivolumab\u2010associated macroscopic duodenitis with spontaneous regression"],"prefix":"10.1002","volume":"8","author":[{"given":"Takatora","family":"Akizawa","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0502-8128","authenticated-orcid":false,"given":"Takeshi","family":"Saraya","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Takakura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masachika","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Pathology Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruyuki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Takizawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kyorin University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_4_2_1","DOI":"10.1200\/JCO.2015.66.1389"},{"doi-asserted-by":"publisher","key":"e_1_2_4_3_1","DOI":"10.1056\/NEJMoa1412082"},{"doi-asserted-by":"publisher","key":"e_1_2_4_4_1","DOI":"10.1001\/jamaoncol.2017.1588"},{"doi-asserted-by":"publisher","key":"e_1_2_4_5_1","DOI":"10.1111\/his.13118"},{"doi-asserted-by":"publisher","key":"e_1_2_4_6_1","DOI":"10.1200\/JCO.2017.77.6385"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:22:54Z","timestamp":1693970574000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/rcr2.582"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.582","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2020,5,11]]},"assertion":[{"value":"2020-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00582"}}