{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:41:42Z","timestamp":1773099702473,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>SMARCA4 (switch\/sucrose non\u2010fermentable\u2010related, matrix\u2010associated, actin\u2010dependent regulator of chromatin, subfamily A, member 4)\u2010deficient thoracic tumours have shown poor prognosis in clinical settings. Although the optimal treatment for SMARCA4\u2010deficient thoracic tumours remains unclear, existing studies indicate a favourable response of these tumours to immune checkpoint inhibitors (ICIs). However, there are no reports of fatality in SMARCA4\u2010deficient small\u2010cell lung carcinoma (SCLC) with hyper\u2010progressive disease (HPD) upon treatment with ICIs. Herein, we report a patient with SMARCA4\u2010deficient SCLC who had HPD after the first ICI treatment. A 35\u2010year\u2010old man was treated with nivolumab, subsequent to cytotoxic chemotherapy. A week after nivolumab initiation, chest computed tomography revealed marked increase in pleural effusion in the right lung and chest wall dissemination of the tumour, which concur with the definition of HPD. This is the first study to report the occurrence of HPD after treatment with ICIs in a patient with SMARCA4\u2010deficient SCLC. Analysis of additional data is necessary to determine the optimal treatment for these patients.<\/jats:p>","DOI":"10.1002\/rcr2.667","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T10:47:01Z","timestamp":1600685221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hyper\u2010progressive disease after immune checkpoint inhibitor in <scp>SMARCA4<\/scp>\u2010deficient small\u2010cell lung carcinoma"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-7544","authenticated-orcid":false,"given":"Yosuke","family":"Chiba","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine University of Occupational and Environmental Health  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Kawanami","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University of Occupational and Environmental Health  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University of Occupational and Environmental Health  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Uchimura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University of Occupational and Environmental Health  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuji","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Pathology and Oncology University of Occupational and Environmental Health  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Yatera","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine University of Occupational and Environmental Health  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.01.002"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13070"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2928"},{"key":"e_1_2_4_5_1","article-title":"A case of SMARCA4\u2010deficient small cell lung carcinoma (in Japanese)","author":"Jotatsu M","year":"2020","journal-title":"Jpn J. 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