{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:22Z","timestamp":1753870162249,"version":"3.41.2"},"reference-count":4,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a rare case of early and extensive pulmonary invasion of malignant pleural mesothelioma (MPM) in a 70\u2010year\u2010old woman. She first presented with a hydropneumothorax and subsequent workup, including video\u2010assisted thoracoscopy (VAT), confirmed MPM. After VAT, she developed dyspnoea, cough, and widespread pulmonary infiltrates of uncertain aetiology. These infiltrates progressed over the following months, failed to respond to antibiotics, and were strongly fluorodeoxyglucose (FDG)\u2010avid on positron emission tomography (PET). Bronchoalveolar lavage (BAL) yielded extremely viscous fluid containing mesothelioma cells. These cells were also found in the sputum when nebulized deoxyribonuclease (DNase) was trialled to enhance clearance of the pulmonary fluid. The patient deteriorated rapidly with progressive mediastinal and contralateral MPM involvement and died one month later. This case highlights the importance of including tumour invasion as a differential diagnosis of non\u2010resolving pulmonary infiltrates in patients with MPM.<\/jats:p>","DOI":"10.1002\/rcr2.675","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T09:32:26Z","timestamp":1603704746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Widespread pulmonary invasion by malignant pleural mesothelioma: an important diagnostic consideration"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0387-3352","authenticated-orcid":false,"given":"Mia","family":"MacMillan","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bapti","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"McLaren","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna K.","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"National Centre for Asbestos Related Diseases University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0036-511X","authenticated-orcid":false,"given":"Y. C. Gary","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"Centre for Respiratory Health, School of Medicine University of Western Australia  Perth WA Australia"},{"name":"Department of Medicine University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jdb7020007"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197810)42:4<1687::AID-CNCR2820420405>3.0.CO;2-N"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01555.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-3204"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.675","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T20:38:47Z","timestamp":1693859927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,26]]},"references-count":4,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/rcr2.675"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.675","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2020,10,26]]},"assertion":[{"value":"2020-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00675"}}