{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:33:51Z","timestamp":1757453631402,"version":"3.41.2"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1136919"],"award-info":[{"award-number":["APP1136919"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001106","name":"New South Wales Workers' Compensation Dust Disease Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001106","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity\u2010dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high viscosity of pleural fluid in mesothelioma. Research into strategies of counteracting HA properties in the management of MPEs may provide further insight.<\/jats:p>","DOI":"10.1002\/rcr2.694","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T07:31:16Z","timestamp":1607067076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hyaluronic acid in viscous malignant mesothelioma pleural effusion"],"prefix":"10.1002","volume":"9","author":[{"given":"Hui Min","family":"Cheah","sequence":"first","affiliation":[{"name":"Pleural Medicine Unit Center for Respiratory Health, University of Western Australia  Perth WA Australia"},{"name":"Medical School University of Western Australia  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8668-1788","authenticated-orcid":false,"given":"Deirdre","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Pleural Medicine Unit Center for Respiratory Health, University of Western Australia  Perth WA Australia"},{"name":"Medical School University of Western Australia  Perth WA Australia"},{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Louw","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine QEII Medical Centre  Perth WA Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenette","family":"Creaney","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia  Perth WA Australia"},{"name":"National Centre for Asbestos Related Diseases  Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0036-511X","authenticated-orcid":false,"given":"Y. 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Gary","family":"Lee","sequence":"additional","affiliation":[{"name":"Pleural Medicine Unit Center for Respiratory Health, University of Western Australia  Perth WA Australia"},{"name":"Medical School University of Western Australia  Perth WA Australia"},{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Joondalup WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.6.1728"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2013.09.016"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071743"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr050247k"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-7709-9_12"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-016-0201-5"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/rcr2.694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T07:46:27Z","timestamp":1693727187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,3]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/rcr2.694"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.694","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2020,12,3]]},"assertion":[{"value":"2020-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00694"}}