{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:50:04Z","timestamp":1780937404043,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allergic bronchopulmonary aspergillosis (ABPA) is common in cystic fibrosis (CF). Treatment is challenging and the relapse rate is high. Standard therapy is oral steroids and antifungals. However, long\u2010term systemic steroid often results in adverse effects and drug interactions between azoles and CFTR modulators are a potential concern. Mepolizumab, an anti\u2010interleukin (IL)\u20105 monoclonal antibody, can benefit patients with severe eosinophilic asthma and there are reports of mepolizumab use in ABPA but not in ABPA complicating CF. We present the case of an adult with CF who had recurrent ABPA and intolerable treatment side effects with steroid, azole, and omalizumab. Mepolizumab was well tolerated and led to significantly improved clinical stability and symptomatic improvement. To our knowledge, this is the first report of successful mepolizumab treatment for ABPA in CF. Mepolizumab may be an important adjunctive treatment for difficult to control ABPA in CF.<\/jats:p>","DOI":"10.1002\/rcr2.696","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T03:43:01Z","timestamp":1606966981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mepolizumab use in cystic fibrosis\u2010associated allergic bronchopulmonary aspergillosis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-8347","authenticated-orcid":false,"given":"Maeve","family":"Boyle","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhain","family":"Mulrennan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"The Faculty of Health and Medical Sciences University of Western Australia  Perth WA Australia"},{"name":"Institute for Respiratory Health  Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Morey","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Vekaria","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"Pharmacy Department Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Popowicz","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"Pharmacy Department Sir Charles Gairdner Hospital  Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sir Charles Gairdner Hospital  Perth WA Australia"},{"name":"The Faculty of Health and Medical Sciences University of Western Australia  Perth WA Australia"},{"name":"Institute for Respiratory Health  Perth WA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/376525"},{"key":"e_1_2_4_3_1","first-page":"CD010834","article-title":"Anti\u2010IL5 therapies for asthma","volume":"9","author":"Farne HA","year":"2017","journal-title":"Cochrane Database Syst. 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