{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:28:53Z","timestamp":1769045333013,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The treatment for empyema thoracis has been evolving over the years, including the usage of intrapleural fibrinolytic therapy (IPFT), for example, alteplase with intrapleural deoxyribonuclease (DNase) to enhance the drainage of pleural effusion. Here, we report two cases of thoracic empyema that were successfully treated with intrapleural saline irrigation and intrapleural tyloxapol apart from parenteral antibiotics as the pillar of the treatment. Both patients averted surgical procedure (decortication) and were discharged well. Upon follow\u2010up, both cases showed clinical cure, biochemical recovery, and radiological improvement, indicating a good treatment outcome. This is the first reported cases on combination of saline irrigation with tyloxapol as alternative treatment for pleural infection.<\/jats:p>","DOI":"10.1002\/rcr2.70000","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T12:14:16Z","timestamp":1723292056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A potential prospect: The novel treatment of intrapleural saline irrigation with intrapleural tyloxapol in treating thoracic empyema"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-5108","authenticated-orcid":false,"given":"Mas Fazlin","family":"Mohamad Jailaini","sequence":"first","affiliation":[{"name":"Respiratory Unit, Faculty of Medicine Universiti Kebangsaan Malaysia (UKM)  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor Amirah","family":"Saini","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Faculty of Medicine Universiti Kebangsaan Malaysia (UKM)  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-6329","authenticated-orcid":false,"given":"Mohd Jazman","family":"Che Rahim","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Faculty of Medicine Universiti Sains Malaysia (USM)  Kota Bharu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7526-361X","authenticated-orcid":false,"given":"Mohamed Faisal","family":"Abdul Hamid","sequence":"additional","affiliation":[{"name":"Respiratory Unit, Faculty of Medicine Universiti Kebangsaan Malaysia (UKM)  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012740"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-022-01995-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00147214"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax-2022-219784"},{"key":"e_1_2_11_6_1","volume-title":"PubChem [Internet]","year":"2004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(19)42280-0"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.13415"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.10.003"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"199","article-title":"Treatment of parapneumonic pleural effusion and empyema\u2013conservative view","volume":"29","author":"Loddenkemper R","year":"2004","journal-title":"Eur Respir Mon"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.137000"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T11:29:21Z","timestamp":1724758161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/rcr2.70000"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70000","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2024-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70000"}}