{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:01:12Z","timestamp":1785297672531,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Filgotinib, a janus kinase 1 (JAK1) inhibitor, is used in the treatment of rheumatoid arthritis (RA). RA\u2010associated interstitial lung disease (RA\u2010ILD) is a severe RA complication with no established effective treatment. We report the case of a patient with RA\u2010ILD successfully treated with filgotinib. A 46\u2010year\u2010old woman with RA and RA\u2010ILD, presenting with a non\u2010specific interstitial pneumonia pattern, was refractory to abatacept and prednisolone but responded to filgotinib. Both arthritis and RA\u2010ILD improved significantly, and the patient remained in remission for over 12\u2009months. Basic research indicates that JAK1 plays a role in the cytokine signal transduction in ILD; however, there are no clinical reports on the efficacy of filgotinib in RA\u2010ILD. This case suggests filgotinib as a potential treatment for patients with RA\u2010ILD, particularly in the early stages of this disease.<\/jats:p>","DOI":"10.1002\/rcr2.70023","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T03:49:27Z","timestamp":1725853767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Successful treatment of rheumatoid arthritis\u2010associated <scp>interstitial lung disease<\/scp> with filgotinib: A case report on <scp>janus kinase 1<\/scp> inhibition"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8346-9216","authenticated-orcid":false,"given":"Atsuhiko","family":"Sunaga","sequence":"first","affiliation":[{"name":"Department of Rheumatology Matsushita Memorial Hospital  Moriguchi\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Matsushita Memorial Hospital  Moriguchi\u2010shi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173806"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-223850"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42861"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S353494"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2021.1902617"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-00936-w"},{"issue":"1","key":"e_1_2_9_8_1","article-title":"Janus kinase inhibitors vs. abatacept about safety and efficacy for patients with rheumatoid arthritis\u2010associated interstitial lung disease: a retrospective nested case\u2010control study. BMC","volume":"8","author":"Tsujii A","year":"2024","journal-title":"Rheumatology"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T06:56:22Z","timestamp":1727592982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":7,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/rcr2.70023"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70023","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-06-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70023"}}