{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:35:41Z","timestamp":1758893741457,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary Langerhans cell histiocytosis (PLCH) is a subtype of Langerhans cell histiocytosis, a rare neoplastic disease characterized by lung involvement. Here, we present a case involving a patient with multiple cavitary nodules who was diagnosed with PLCH during surveillance after lung cancer surgery. A 74\u2010year\u2010old woman underwent right upper lobe resection surgery for right upper lobe lung adenocarcinoma, pStage IIA, 5\u2009years ago. The patient underwent surveillance without adjuvant chemotherapy. During the fifth year of follow\u2010up, multiple nodules with cavitation were observed on computed tomography in both lung fields. Chemotherapy was considered to address the suspected recurrence of lung cancer; however, video\u2010assisted thoracoscopic surgery was performed due to the need for biomarker testing. Pathological examination led to the diagnosis of PLCH. This case emphasizes the importance of a proactive histological diagnosis to determine the appropriate treatment strategy, even in situations where lung cancer recurrence is clinically suspected.<\/jats:p>","DOI":"10.1002\/rcr2.70028","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T05:40:44Z","timestamp":1726724444000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pulmonary Langerhans cell histiocytosis with multiple cavitary nodules after lung cancer surgery"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3949-8928","authenticated-orcid":false,"given":"Minoru","family":"Sugihara","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Komaki City Hospital  Komaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawako","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Komaki City Hospital  Komaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Komaki City Hospital  Komaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1183\/16000617.0070-2017"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1159\/000084043"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1002\/cam4.1844"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1002\/1097-0142(19930201)71:3<865::AID-CNCR2820710334>3.0.CO;2-0"},{"key":"e_1_2_10_6_1","article-title":"BRAF\u2010mutant pulmonary Langerhans cell histiocytosis mimicking recurrence of early\u2010stage KRAS\u2010mutant lung adenocarcinoma","volume":"2","author":"Alden SL","year":"2020","journal-title":"JTO Clin Res Rep"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T06:56:18Z","timestamp":1727592978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":5,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/rcr2.70028"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70028","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"2024-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70028"}}