{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:25Z","timestamp":1753870165239,"version":"3.41.2"},"reference-count":5,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of infective endocarditis (IE) due to nasal septal perforation during Home oxygen therapy (HOT). A 64\u2010year\u2010old man with a history of interstitial pneumonia (IP) and on HOT was hospitalized for dyspnea. Methicillin\u2010sensitive <jats:italic>Staphylococcus aureus<\/jats:italic> (MSSA) was repeatedly detected in blood cultures. Echocardiography revealed tricuspid valve vegetation and regurgitation. The patient was diagnosed with IE, according to the modified Duke criteria. A full\u2010body examination revealed nasal septal perforation and MSSA was isolated from the nasal cavity. The patient was treated with cefazolin and clindamycin. However, he developed aspiration pneumonia and subsequently died. The portal of entry of MSSA was damaged nasal mucosa, caused by dryness and curettage of the dried nasal mucus during HOT. Nasal septal perforation, a potential complication of HOT, may cause severe bacterial infections. Consequently, diligent nasal care is crucial during HOT.<\/jats:p>","DOI":"10.1002\/rcr2.70038","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T09:09:13Z","timestamp":1728292153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Infective endocarditis due to nasal septal perforation during home oxygen therapy"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-9916","authenticated-orcid":false,"given":"Kyota","family":"Shinfuku","sequence":"first","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Takasaka","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryutaro","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Division of General Practice, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiki","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Radiology The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Takatsuka","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Mita","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Yamada","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumie","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Hosaka","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Ryu","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokio","family":"Hoshina","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Infection Control The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"},{"name":"Department of Infectious Diseases and Infection Control The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University Daisan Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Araya","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases, Department of Internal Medicine The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1063","article-title":"AARC clinical practice guideline. 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