{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:25Z","timestamp":1753870165728,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ramucirumab (RAM) has been approved for the treatment of non\u2010small cell lung cancer (NSCLC). Here, we report two cases of RAM\u2010induced ascites with epidermal growth factor receptor\u2010mutant NSCLC. Patient 1, a 72\u2010year\u2010old man, developed ascites 20\u2009months after erlotinib (ERL) and RAM administration, which resolved after their discontinuation and performing paracentesis. Patient 2, an 83\u2010year\u2010old woman, developed ascites 9\u2009months after ERL and RAM administration, which resolved after RAM discontinuation and furosemide administration. Ramucirumab administration can cause ascites due to increased hepatic sinusoidal pressure. Clinicians should be aware of RAM\u2010induced ascites in patients with NSCLC and should appropriately manage it.<\/jats:p>","DOI":"10.1002\/rcr2.70046","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T02:39:53Z","timestamp":1728959993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ramucirumab\u2010induced ascites with endothelial growth factor receptor mutation\u2010positive non\u2010small cell lung cancer: Two case reports"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2383-9532","authenticated-orcid":false,"given":"Keisuke","family":"Shiraha","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Iwakuni Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-9029","authenticated-orcid":false,"given":"Tomoki","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Iwakuni Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisaku","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Iwakuni Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Umeno","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Iwakuni Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Nishii","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Iwakuni Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Kuyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Iwakuni Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx514"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00050-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30634-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.23312"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13691-019-00366-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60845-X"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13638"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-020-01668-w"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(05)70177-X"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2021.2241"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507889"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T04:39:54Z","timestamp":1730090394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/rcr2.70046"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70046","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70046"}}