{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:26Z","timestamp":1753870166857,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A third of patients with non\u2010Hodgkin's lymphoma (NHL) develop pleural effusion during the disease course for various reasons. In most cases, lymphoma\u2010related pleural effusion is a manifestation of widespread systemic disease, signifying a high tumour burden and therefore, a poorer prognosis. On the other hand, primary pleural lymphomas (PPLs) exhibit exclusive or dominant involvement of serous cavities, without detectable solid tumour masses. PPL is an uncommon disease and is of two types: primary effusion lymphoma (PEL) and diffuse large B\u2010cell lymphoma associated with chronic inflammation (DLBCL\u2010CI). PPLs not related to PELs and DLBCL\u2010CIs are exceedingly rare. Herein, we describe four patients with biopsy proven B\u2010cell NHL. One had no extra\u2010pleural involvement at the time of diagnosis, indicating PPL. In all cases, histopathological examination of pleural biopsies obtained via medical thoracoscopy (MT) were crucial in clinching the final diagnosis. Clinicians are alerted to the potential relationship between exudative effusion and NHL as well as the role of MT in the diagnosis of B\u2010cell NHL.<\/jats:p>","DOI":"10.1002\/rcr2.70061","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T09:13:26Z","timestamp":1732007606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilizing medical thoracoscopy for the diagnosis of B\u2010cell lymphoma presenting with pleural effusion: A case series"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-4189","authenticated-orcid":false,"given":"Nai\u2010Chien","family":"Huan","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Queen Elizabeth Hospital  Kota Kinabalu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-1398","authenticated-orcid":false,"given":"Khai Lip","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Medicine Melaka Hospital  Melaka Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5790-3919","authenticated-orcid":false,"given":"Larry Ellee","family":"Nyanti","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Queen Elizabeth Hospital  Kota Kinabalu Malaysia"},{"name":"Medical Department, Faculty of Medicine and Health Sciences University Malaysia Sabah  Kota Kinabalu Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing Yi","family":"Khaw","sequence":"additional","affiliation":[{"name":"Department of Medicine Melaka Hospital  Melaka Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiun Hang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Queen Elizabeth Hospital  Kota Kinabalu 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