{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:15:35Z","timestamp":1763644535899,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Granulomatous\u2010lymphocytic interstitial lung disease (GL\u2010ILD) is a rare pulmonary complication associated with common variable immunodeficiency (CVID), complicating diagnosis due to overlapping symptoms with other chronic respiratory conditions. This case involves a 33\u2010year\u2010old male with a history of sarcoidosis, presenting with recurrent sino\u2010pulmonary infections, mediastinal and axillary lymphadenopathy, and significant splenomegaly. Despite initial treatment with prednisolone, his symptoms persisted, and FDG\u2010PET imaging showed metabolic activity in the sinuses and lymph nodes. Immunological assessment revealed markedly reduced immunoglobulin levels, leading to intravenous immunoglobulin (IVIG) therapy, which resulted in substantial improvement. A critical learning point is recognising that splenomegaly is commonly associated with CVID, which can aid in distinguishing it from other conditions. This case underscores the importance of considering CVID, with or without GL\u2010ILD, as a differential diagnosis in patients with persistent respiratory symptoms and granulomatous lung disease, including sarcoidosis. Further research is needed to optimise treatment strategies for this rare condition.<\/jats:p>","DOI":"10.1002\/rcr2.70102","type":"journal-article","created":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T01:28:11Z","timestamp":1738459691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unravelling Granulomatous\u2010Lymphocytic Interstitial Lung Disease: A Case of Common Variable Immunodeficiency With Unusual Clinical Features and Response to Intravenous Immunoglobulin"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0831-8505","authenticated-orcid":false,"given":"Nirosha","family":"Pragash","sequence":"first","affiliation":[{"name":"Department of Thoracic Medicine Peninsula Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine Peninsula Health  Melbourne Victoria Australia"},{"name":"The Institute for Breathing and Sleep  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Antonov","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine Peninsula Health  Melbourne Victoria Australia"},{"name":"Monash Lung Sleep Allergy and Immunology Monash Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"1","article-title":"Granulomatous Lymphocyte Interstitial Lung Disease: A Rare Complication of Common Variable Immunodeficiency Managed With Azathioprine and Rituximab","volume":"16","author":"Khreisat A.","year":"2024","journal-title":"Cureus"},{"issue":"4","key":"e_1_2_8_3_1","first-page":"938","article-title":"British Lung Foundation\/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous\u2010Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders","volume":"5","author":"Hurst J. 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G.","year":"1980","journal-title":"Acta Medica Scandinavica"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.02004.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-007-9075-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.05.057"},{"issue":"5","key":"e_1_2_8_12_1","first-page":"510","article-title":"Bronchiectasis and Granulomatous\u2010Lymphocytic Interstitial Lung Disease (GL\u2010ILD) in Common Variable Immunodeficiency: Diagnostic Challenges and Co\u2010Occurrence","volume":"40","author":"Cunningham M. A.","year":"2020","journal-title":"Journal of Clinical Immunology"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T06:32:20Z","timestamp":1743834740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/rcr2.70102"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70102","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70102"}}