{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:30:54Z","timestamp":1788546654381,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016341","name":"Korea University Guro Hospital","doi-asserted-by":"publisher","award":["K2115711"],"award-info":[{"award-number":["K2115711"]}],"id":[{"id":"10.13039\/100016341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Lazertinib is a third\u2010generation epidermal growth factor receptor tyrosine kinase inhibitor effective in patients with non\u2010small cell lung cancer. Although generally well tolerated, this case report presents a rare occurrence of common terminology criteria for adverse events grade 3 rhabdomyolysis in a 69\u2010year\u2010old Korean woman after taking lazertinib. The patient exhibited general weakness and tea\u2010coloured urine with elevated levels of creatine phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), serum myoglobin and hyperkalemia. Lazertinib was temporarily discontinued, and urine alkalization was initiated. After the patient's condition improved, lazertinib was restarted at a reduced dose (80\u2009mg) without any adverse effects. This case highlights the importance of assessing CPK and LDH levels in patients undergoing treatment with lazertinib, particularly in those with myalgia and elevated AST levels. Further studies are required to clarify the mechanisms underlying lazertinib\u2010induced rhabdomyolysis.<\/jats:p>","DOI":"10.1002\/rcr2.70105","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T08:35:11Z","timestamp":1738744511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lazertinib\u2010Induced Rhabdomyolysis in a Patient With Non\u2010Small Cell Lung Cancer: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8125-8240","authenticated-orcid":false,"given":"Seunghun","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6536-9763","authenticated-orcid":false,"given":"Juwhan","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-5792","authenticated-orcid":false,"given":"Sung Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00515"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2010.151"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.8168-21"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-22-916"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071770"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T06:31:48Z","timestamp":1743834708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/rcr2.70105"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70105","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70105"}}