{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T06:17:37Z","timestamp":1788675457905,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report a rare case of pembrolizumab\u2010induced anti\u2010Yo\u2010antibody\u2010positive cerebellitis in a patient with stage IV lung adenocarcinoma. Following two cycles of combination therapy, the patient developed nystagmus and ataxia. Despite tumour regression and normal magnetic resonance imaging (MRI) findings, cerebrospinal fluid analysis revealed lymphocyte\u2010dominant hypercellularity, increased protein, and oligoclonal bands. Immune checkpoint inhibitor (ICI)\u2010related cerebellitis was diagnosed after excluding infectious causes, metastases, and cancerous meningitis coupled with a positive anti\u2010Yo antibody. Methylprednisolone pulse was ineffective, but high\u2010dose intravenous immunoglobulin therapy resolved symptoms. To the best of our knowledge, this is the first case report of ICI\u2010related cerebellitis with anti\u2010Yo\u2010antibody in lung adenocarcinoma. This case highlights the importance of paraneoplastic antibody testing in diagnosing ICI\u2010related encephalitis, especially in cases of normal MRI findings.<\/jats:p>","DOI":"10.1002\/rcr2.70160","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T20:44:18Z","timestamp":1742849058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pembrolizumab\u2010Induced Anti\u2010Yo\u2010Antibody\u2010Positive Cerebellitis: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5507-2178","authenticated-orcid":false,"given":"Takafumi","family":"Yamano","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Kurashiki Central Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihide","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kurashiki Central Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kurashiki Central Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocpiqo.2017.12.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2014.07.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.42.10.1931"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(23)00369\u20101"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6385"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T04:01:40Z","timestamp":1751342500000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/rcr2.70160"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70160","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2025-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70160"}}