{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:35Z","timestamp":1753870175722,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report a rare case of recrudescence of natalizumab\u2010induced pneumonitis and peripheral hypereosinophilia, hence uniquely satisfying the re\u2010exposure principle outlined by the Naranjo Adverse Drug Reaction Probability Scale. A 57\u2010year\u2010old female with relapsing\u2013remitting multiple sclerosis presented with acute respiratory symptoms, eosinophilia of 2.08\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, and chest computed tomography showing consolidation of the right upper and lower lobes. Her septic and autoimmune work\u2010up was negative. She did not improve with broad\u2010spectrum antibiotics. Bronchoalveolar lavage revealed 75% lymphocytes. Upon discussion at a multi\u2010disciplinary meeting, her antibiotics were discontinued and she was commenced on prednisolone, which resulted in immediate improvement. She experienced two further recurrences of pneumonitis during her prednisolone tapering. After a two\u2010year remission, she was re\u2010started on natalizumab due to adverse events related to alternative biologic agents. Her pneumonitis and peripheral hypereosinophilia recurred. She responded well to another course of prednisolone, and subsequent follow\u2010up revealed complete recovery off natalizumab.<\/jats:p>","DOI":"10.1002\/rcr2.70191","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:46:37Z","timestamp":1745577997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recrudescence of Natalizumab\u2010Induced Pneumonitis and Peripheral Hypereosinophilia: Case Report and\u00a0Literature Review"],"prefix":"10.1002","volume":"13","author":[{"given":"Gerardo","family":"Arwi","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Eastern Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-8194","authenticated-orcid":false,"given":"Louis","family":"Chhor","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Eastern Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Malipatil","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine Eastern Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044397"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051847"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10811-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.185762"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S225832"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10040638"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7100356"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00085603"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2021.577505"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-939522"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T02:55:36Z","timestamp":1745895336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/rcr2.70191"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70191","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70191"}}