{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:02:24Z","timestamp":1792342944605,"version":"4.4.0"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Tumour seeding following biopsy is a rare but clinically significant complication in lung cancer diagnostics, particularly in aggressive malignancies. A 66\u2010year\u2010old male with a significant smoking history and known chronic obstructive pulmonary disease presented with chronic cough and weight loss. Imaging revealed a central airway mass with mediastinal lymphadenopathy. Bronchoscopic evaluation and biopsy confirmed the diagnosis of metastatic non\u2010small cell lung cancer with high PD\u2010L1 expression. Shortly after the initial procedure, the patient developed airway obstruction due to a rapidly growing endobronchial lesion at the prior biopsy site, confirmed histologically as tumour seeding. Multiple bronchoscopic interventions were required to restore airway patency. Despite prompt escalation to combined chemo\u2010immunotherapy and repeated multimodal airway recanalisation, the disease demonstrated aggressive local recurrence. This case highlights the potential for endobronchial tumour seeding following diagnostic interventions in lung cancer, underscoring the importance of vigilant follow\u2010up and prompt management in cases with rapid disease progression.<\/jats:p>","DOI":"10.1002\/rcr2.70193","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T08:30:26Z","timestamp":1746606626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tumour Seeding After Transbronchial Cryobiopsy in\u00a0a Patient With Newly Diagnosed Lung Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5774-074X","authenticated-orcid":false,"given":"Sammy","family":"Onyancha","sequence":"first","affiliation":[{"name":"Department of Pulmonology St. Elisabethen Krankenhaus  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Dettmer","sequence":"additional","affiliation":[{"name":"Department of Pulmonology St. Elisabethen Krankenhaus  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Njuxhersa","family":"Maloku","sequence":"additional","affiliation":[{"name":"Department of Pulmonology St. Elisabethen Krankenhaus  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Pulmonology St. Elisabethen Krankenhaus  Frankfurt Germany"},{"name":"Medical Clinic I, Department of Respiratory Medicine Goethe University Frankfurt, University Hospital  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.cr.20\u201000271"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759\u20107714.14600"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.9273"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.9360"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.241661"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T11:39:04Z","timestamp":1748432344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/rcr2.70193"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70193","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70193"}}