{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:45:17Z","timestamp":1782963917557,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Gastrointestinal metastasis from primary lung cancer is uncommon and metastasis to the appendix is particularly rare. It often presents with symptoms of acute appendicitis or remains asymptomatic, leading to incidental diagnosis. We report a rare case of lung cancer with metastasis to the appendix presenting as acute appendicitis. A 74\u2010year\u2010old male patient with a history of severe COPD was diagnosed with advanced\u2010stage lung cancer and had been receiving targeted therapy for over a year. He subsequently developed acute appendicitis and underwent an appendectomy. Histopathological examination of the appendix revealed adenocarcinoma infiltrating the serosa of the appendix and immunohistochemistry staining was consistent with a primary adenocarcinoma lung cancer. Metastasis of lung cancer to the appendix is an extremely rare occurrence. This case highlights the diverse clinical manifestations in patients with metastatic lung cancer and underscores the importance of considering differential diagnoses for the aetiology of acute appendicitis, as it may be secondary metastasis.<\/jats:p>","DOI":"10.1002\/rcr2.70200","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T06:17:07Z","timestamp":1746425827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute Appendicitis due to Rare Metastasis From Lung Cancer: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Khanh Toan","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Medical Oncology 2 Nghe An Oncology Hospital  Nghe An Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1642-8137","authenticated-orcid":false,"given":"Do Mai","family":"Linh","sequence":"additional","affiliation":[{"name":"Department of Oncology Hanoi Medical University  Hanoi Vietnam"},{"name":"Department of Medical Oncology 1 Vietnam National Cancer Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Huong","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology 2 Nghe An Oncology Hospital  Nghe An Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Lam","family":"Ngo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology 2 Nghe An Oncology Hospital  Nghe An Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Hai Yen","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology 2 Nghe An Oncology Hospital  Nghe An Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Khanh Ha","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology 2 Nghe An Oncology Hospital  Nghe An Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Phuong Nhu","family":"Vo","sequence":"additional","affiliation":[{"name":"Pathology Department Nghe an Oncology Hospital  Nghe An Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Truong Thi Kieu","family":"Oanh","sequence":"additional","affiliation":[{"name":"Department of Oncology Hanoi Medical University  Hanoi Vietnam"},{"name":"Department of on\u2010Demand Breast Gynecologic, Head and Neck Medical Oncology, Hanoi Oncology Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4011-6434","authenticated-orcid":false,"given":"Le Thi Thu","family":"Nga","sequence":"additional","affiliation":[{"name":"Cancer Institute, 108 Military Central Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.08.1907"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2010.4.3.351"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jrras.2023.100575"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.7617"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40792\u2010021\u201001196\u20106"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i15.1961"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.08.030"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.12659\/ajcr.920010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2011.6.6826"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.703"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjad101"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2020.10.116"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40792\u2010018\u20100467\u20107"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6382"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"56","article-title":"Lung Cancer: Diagnosis and Management","volume":"75","author":"Collins L. 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