{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:35Z","timestamp":1753870175827,"version":"3.41.2"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Chylothorax, the accumulation of lymphatic fluid in the pleural space, is a rare condition often linked to trauma, surgery or malignancy. We present the case of a 63\u2010year\u2010old female with a significant smoking history who was diagnosed with chylothorax as the initial manifestation of small cell lung carcinoma (SCLC). Diagnostic workup, including pleural fluid analysis and imaging, confirmed the diagnosis and revealed mediastinal lymphadenopathy and bronchial narrowing. The patient underwent chemotherapy, immunotherapy and management of recurrent effusions but ultimately succumbed to pneumonia and septic shock. Recognising chylothorax as a potential initial manifestation and understanding the risks of prolonged chyle drainage are crucial for effectively managing such complex cases.<\/jats:p>","DOI":"10.1002\/rcr2.70202","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T04:38:31Z","timestamp":1746506311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chylothorax as the Initial Manifestation of Small Cell Lung Carcinoma"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3321-0914","authenticated-orcid":false,"given":"Sathish","family":"Krishnan","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Community Health Network  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anam","family":"Naumaan","sequence":"additional","affiliation":[{"name":"Division of Anatomic and Clinical Pathology Community Health Network  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venu","family":"Pararath Gopalakrishnan","sequence":"additional","affiliation":[{"name":"University of Massachusetts Chan Medical School  Worcester Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2015.02.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2278\u20100513.138068"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00470\u20102024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd\u201023\u20101636"},{"issue":"4","key":"e_1_2_8_6_1","article-title":"Chylothorax Associated With Sarcoidosis: A Review of the Literature","volume":"39","author":"Israeli\u2010Shani L.","year":"2022","journal-title":"Sarcoidosis, Vasculitis, and Diffuse Lung Diseases"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100030\u20101269834"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0163\u20102021"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcr.2024.101101"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2004.06.016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.10.024"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1891\/11\u2010T\u2010705"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T11:38:47Z","timestamp":1748432327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/rcr2.70202"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70202","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70202"}}