{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T09:02:45Z","timestamp":1780822965769,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti\u2010neutrophil cytoplasmic antibody (ANCA)\u2010associated vasculitis characterised by asthma, eosinophilia, and systemic inflammation, often involving the lungs. We present the case of a 47\u2010year\u2010old woman with EGPA who developed progressive ground\u2010glass opacities and a crazy\u2010paving pattern on chest computed tomography (CT). Bronchoalveolar lavage revealed milky fluid, and transbronchial lung biopsy showed periodic acid\u2010Schiff (PAS)\u2010positive eosinophilic granular material. Elevated anti\u2010granulocyte\u2010macrophage colony\u2010stimulating factor (GM\u2013CSF) antibodies confirmed a diagnosis of autoimmune pulmonary alveolar proteinosis (aPAP). Corticosteroid tapering initially led to EGPA relapse, which was successfully controlled with mepolizumab, enabling further steroid reduction. Following this, the radiological findings of aPAP showed gradual improvement. In rare cases, it is known that autoimmune diseases such as vasculitis can be complicated by aPAP. This case highlights the importance of individualised immunomodulatory treatment and close imaging follow\u2010up in patients with overlapping autoimmune conditions.<\/jats:p>","DOI":"10.1002\/rcr2.70219","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T11:13:59Z","timestamp":1747739639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of Autoimmune Pulmonary Alveolar Proteinosis Developing During the Course of Eosinophilic Granulomatosis With Polyangiitis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0889-991X","authenticated-orcid":false,"given":"Yoichi","family":"Dotake","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Graduate School of Medical and Dental Sciences, Kagoshima University  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Graduate School of Medical and Dental Sciences, Kagoshima University  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Fujisaki","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Graduate School of Medical and Dental Sciences, Kagoshima University  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Shimobaba","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Graduate School of Medical and Dental Sciences, Kagoshima University  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Kuroiwa","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Graduate School of Medical and Dental 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Graduate School of Medical and Dental Sciences, Kagoshima University  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Graduate School of Medical and Dental Sciences, Kagoshima University  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2009.02.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11122318"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200708-1271OC"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-14-172"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.243.77"}],"container-title":["Respirology Case 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