{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:09:37Z","timestamp":1753870177545,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Intravascular large B\u2010cell lymphoma (IVLBCL) is a rare and aggressive extranodal lymphoma characterised by the proliferation of malignant lymphocytes within the lumens of blood vessels. Diagnosing IVLBCL is often challenging due to its nonspecific clinical presentation and difficulty in obtaining histopathologic confirmation. Here, we present a case of IVLBCL diagnosed by transbronchial lung cryobiopsy (TBLC). A 68\u2010year\u2010old man was initially diagnosed with diffuse large B\u2010cell lymphoma based on an orchiectomy specimen. Although initial treatment achieved complete remission, tumour marker levels progressively increased during follow\u2010up. TBLC was performed after bone marrow biopsy, cerebrospinal fluid cytology, and a random skin biopsy failed to detect lymphoma lesions. Histological findings of the TBLC specimen demonstrated medium\u2010sized atypical lymphocytes filling the blood vessels, leading to a diagnosis of IVLBCL. Cryobiopsy specimens allow for the evaluation of alveolar structure and microvasculature, making it a valuable and less invasive diagnostic option for pulmonary IVLBCL.<\/jats:p>","DOI":"10.1002\/rcr2.70226","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T13:19:59Z","timestamp":1750079999000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Intravascular Large B\u2010Cell Lymphoma Diagnosed by Transbronchial Lung Cryobiopsy: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-2254","authenticated-orcid":false,"given":"Yen Shen","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"},{"name":"Faculty of Medicine Universiti Teknologi MARA  Sungai Buloh Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-5155","authenticated-orcid":false,"given":"Hideaki","family":"Furuse","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"},{"name":"Department of Thoracic Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Tsuchida","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Respiratory Endoscopy Division National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2313"},{"key":"e_1_2_9_3_1","first-page":"177","volume-title":"WHO Classification Tumours of Haematopoietic and Lymphoid Tissues","author":"KC G","year":"2001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2022.02.006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-737445"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016151706"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2016140339"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.1.182"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0280-2021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.10.048"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1091-1"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T15:59:07Z","timestamp":1750953547000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/rcr2.70226"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70226","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70226"}}