{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:18:36Z","timestamp":1787167116111,"version":"build-2736575974"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We report a case of chylothorax secondary to severe mitral regurgitation, in the absence of heart failure with a low ejection fraction. A 49\u2010year\u2010old male presented with mitral valve infective endocarditis, complicated by severe mitral regurgitation with persistent vegetations 5\u2009weeks into treatment. He declined valvular repair. He was admitted four times in the following year for symptomatic right pleural effusion requiring therapeutic chest drainage. Pleural fluid was milky, with elevated triglyceride levels consistent with chylothorax. He underwent mitral valve replacement, with no recurrence of chylothorax to date. The mechanism of chylothorax in mitral regurgitation is likely due to high central venous pressure, with transmitted high right lymphatic duct and thoracic duct pressures. This may then cause reflux of lymph and chyle into pleural lymphatics and subsequent leakage of fluid into the pleural space. This case illustrates mitral regurgitation as a rare cause of chylothorax, with mitral valve replacement granting remission.<\/jats:p>","DOI":"10.1002\/rcr2.70229","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T09:16:46Z","timestamp":1750065406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Refractory Chylothorax in a Patient With Severe Mitral Regurgitation"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3469-1529","authenticated-orcid":false,"given":"Sheena Jing Yi","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Respiratory &amp; Critical Care Medicine Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao Li","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Critical Care Medicine Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken Junyang","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Critical Care Medicine Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Ling","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Critical Care Medicine Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Lee Wei","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Critical Care Medicine Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Jing Yi","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Critical Care Medicine Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana Gilcrist","family":"Phua","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Critical Care Medicine Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Ting","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Critical Care Medicine Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie Kah\u2010Lai","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Respiratory &amp; Critical Care Medicine Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/80.7.867"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5543\/tkda.2011.01447"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.73.5.672"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.06.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.04.024"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T11:59:21Z","timestamp":1750939161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/rcr2.70229"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70229","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70229"}}