{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:57:10Z","timestamp":1782755830245,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016646","name":"HCA Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We present the case of a female in her 20s with a history of obesity and obstructive sleep apnea (OSA) on continuous positive airway pressure (CPAP) therapy, who developed silent microaspiration pneumonitis and organising pneumonia (OP) following the recent initiation of Semaglutide for weight loss. She initially presented with shortness of breath, a non\u2010productive cough and subjective fevers of 1\u2010week duration. On admission, she was hypoxic, requiring 6\u2009L of oxygen via nasal cannula and chest imaging revealed right lung infiltrates concerning for community\u2010acquired pneumonia. Despite completing antibiotics, her symptoms and imaging progressively worsened. An extensive infectious and autoimmune workup was conducted, but no clear aetiology was identified. Diagnostic bronchoscopy revealed severe gastroesophageal reflux disease (GERD) with evidence of microaspiration, leading to the diagnosis of organising pneumonia (OP) secondary to silent aspiration. Although long\u2010acting glucagon\u2010like peptide\u20101 (GLP\u20101) agonists like Semaglutide do not typically cause reflux, they are known to delay gastric emptying, which can increase intragastric pressure. In this patient, the combination of delayed gastric emptying from Semaglutide, obesity and CPAP therapy likely contributed to reflux and silent aspiration. The patient was successfully treated with corticosteroids and proton pump inhibitors, resulting in clinical and radiographic improvement. This case highlights the potential for silent aspiration in patients on GLP\u20101 receptor agonists, especially those on CPAP therapy, and underscores the importance of monitoring for reflux\u2010related complications in these patients.<\/jats:p>","DOI":"10.1002\/rcr2.70249","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T06:39:31Z","timestamp":1751611171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Semaglutide\u2010Induced Silent Aspiration: An Unrecognised Cause of Organising Pneumonia"],"prefix":"10.1002","volume":"13","author":[{"given":"Kobina","family":"Essilfie\u2010Quaye","sequence":"first","affiliation":[{"name":"University of Central Florida College of Medicine, Graduate Medical Education  Orlando Florida USA"},{"name":"HCA Florida North Florida Hospital, Internal Medicine Residency Program  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2541-9373","authenticated-orcid":false,"given":"Geran","family":"Maule","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine, Graduate Medical Education  Orlando Florida USA"},{"name":"HCA Florida North Florida Hospital, Internal Medicine Residency Program  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husham","family":"Hashim","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine, Graduate Medical Education  Orlando Florida USA"},{"name":"HCA Florida North Florida Hospital, Internal Medicine Residency Program  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Khraisat","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine, Graduate Medical Education  Orlando Florida USA"},{"name":"HCA Florida North Florida Hospital, Internal Medicine Residency Program  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peters","family":"Okonoboh","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine, Graduate Medical Education  Orlando Florida USA"},{"name":"HCA Florida North Florida Hospital, Internal Medicine Residency Program  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jantz","sequence":"additional","affiliation":[{"name":"University of Central Florida College of Medicine, Graduate Medical Education  Orlando Florida USA"},{"name":"HCA Florida North Florida Hospital, Internal Medicine Residency Program  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae719"},{"issue":"10","key":"e_1_2_9_4_1","first-page":"E1247","article-title":"Retained Gastric Content Despite Prolonged Fasting in Patients on GLP\u20101 Receptor Agonists Undergoing Endoscopy","volume":"11","author":"Aminian A.","year":"2023","journal-title":"Endoscopy International Open"},{"issue":"1","key":"e_1_2_9_5_1","article-title":"Case Reports of Aspiration in Patients Using Semaglutide for Weight Loss Despite Fasting","volume":"17","author":"Hanna M. G.","year":"2024","journal-title":"BMJ Case Reports"},{"key":"e_1_2_9_6_1","volume-title":"Consensus\u2010Based Guidance on Preoperative Management of Patients (Adults and Children) on Glucagon\u2010Like Peptide\u20101 (GLP\u20101) Receptor Agonists","author":"Joshi G. P.","year":"2023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2020.11.021"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308\u20101483ST"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-2401-6_24"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.66311"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27278"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.4.369"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:43:19Z","timestamp":1758721399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/rcr2.70249"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70249","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70249"}}