{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:10:22Z","timestamp":1758723022698,"version":"3.44.0"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A previously healthy 63\u2010year\u2010old woman, unvaccinated for influenza A, had a mild fever for a week followed by alerted consciousness. On the day of admission, she developed shortness of breath, high fever, hypotension and alterations of consciousness. Chest CT revealed rapidly progressing bilateral infiltrates. She was diagnosed with disseminated intravascular coagulation, hypogammaglobulinemia and acute renal failure, requiring intensive care for respiratory failure and hypotension. A Sputum FilmArray Pneumonia Panel (PN panel) performed on admission identified multiple pathogens, including influenza A virus and <jats:styled-content style=\"fixed-case\"><jats:italic>Streptococcus pyogenes<\/jats:italic><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\"><jats:italic>S. pyogenes<\/jats:italic><\/jats:styled-content>), although only <jats:styled-content style=\"fixed-case\"><jats:italic>S. pyogenes<\/jats:italic><\/jats:styled-content> was cultured from bronchoalveolar lavage fluid. Intensive care, including antibiotics and steroids, led to clinical improvement. Blood cultures remained negative throughout the course. Even healthy adults can develop severe <jats:styled-content style=\"fixed-case\"><jats:italic>S. pyogenes<\/jats:italic><\/jats:styled-content> pneumonia following influenza A infection. Rapid bacterial identification by PN panel and bronchoscopy, along with an appropriate treatment strategy, may improve outcomes.<\/jats:p>","DOI":"10.1002\/rcr2.70267","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T07:10:37Z","timestamp":1752131437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Severe Case of <i>Streptococcus pyogenes<\/i> Pneumonia Following Influenza A Virus Infection Diagnosed by <scp>FilmArray<\/scp> Pneumonia Panel and Bronchoalveolar Lavage"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3587-9560","authenticated-orcid":false,"given":"Koji","family":"Matsuda","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Teine Keijinkai Hospital  Sapporo Japan"},{"name":"Internal Medicine Residency Program Teine Keijinkai Hospital  Sapporo 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Keijinkai Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency Program Teine Keijinkai Hospital  Sapporo Japan"},{"name":"Department of Infectious Disease Teine Keijinkai Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medical Center Teine Keijinkai Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medical Center Teine Keijinkai Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nara","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Medical 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