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Ocrelizumab is an anti\u2010CD20 monoclonal antibody widely used as a disease\u2010modifying therapy for relapsing\u2013remitting and primary progressive forms of multiple sclerosis (MS). We describe two cases of biopsy\u2010proven secondary OP in ocrelizumab\u2010treated MS patients occurring several weeks after contracting COVID\u201019 infection. These cases had been on ocrelizumab for 6.5\u2009years (latent period) before the development of OP. Withdrawal of ocrelizumab and corticosteroids resulted in clinical and radiographic recovery. Literature review revealed seven cases of secondary OP in ocrelizumab\u2010treated MS patients without evidence of infection and 10 MS cases with secondary OP due to COVID\u201019 infection in the setting of ocrelizumab treatment. Although unproven, ocrelizumab could trigger pneumotoxicity in patients when combined with COVID infection.<\/jats:p>","DOI":"10.1002\/rcr2.70268","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T13:03:53Z","timestamp":1752066233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Secondary Organising Pneumonia Among Immunocompromised Multiple Sclerosis Patients Treated With Ocrelizumab Following <scp>COVID<\/scp>\u201019 Infection: Two Case Reports With Literature Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6705-5781","authenticated-orcid":false,"given":"Tarake M.","family":"Aljarod","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine Marshall University School of Medicine  Huntington West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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