{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:10:01Z","timestamp":1758723001987,"version":"3.44.0"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Osimertinib, a standard treatment for epidermal growth factor receptor (EGFR)\u2010positive non\u2010small\u2010cell lung cancer, commonly causes manageable diarrhoea. We report osimertinib\u2010induced refractory diarrhoea diagnosed as ulcerative colitis, remitting with mesalazine. A 69\u2010year\u2010old woman with advanced\u2010stage EGFR mutation\u2010positive lung adenocarcinoma developed persistent diarrhoea 3\u2009weeks after starting osimertinib, complicated by anorexia, hypotension, anaemia and renal failure requiring hospitalisation. While anaemia and renal failure improved after osimertinib cessation, diarrhoea persisted. A colonoscopy revealed ulcerative colitis, confirmed by neutrophil and lymphocyte infiltration in the intestinal mucosa, glandular deformation and decreased goblet cells. This case demonstrates that osimertinib\u2010induced ulcerative colitis was successfully treated with mesalazine.<\/jats:p>","DOI":"10.1002\/rcr2.70272","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T10:05:17Z","timestamp":1752141917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case Report on the Development of Ulcerative Colitis During Osimertinib Therapy for Epidermal Growth Factor Receptor Mutation\u2010Positive Non\u2010Small\u2010Cell Lung Cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-9029","authenticated-orcid":false,"given":"Tomoki","family":"Tamura","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misaki","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Osedo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisaku","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Umeno","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Kuyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine NHO Iwakuni Clinical Center  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-015-0279-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27353-w"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.02.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013136"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.4c00098"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:43:10Z","timestamp":1758721390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/rcr2.70272"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70272","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70272"}}