{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:21:04Z","timestamp":1780982464302,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Pulmonary adenoid cystic carcinoma (PACC) is a rare salivary gland\u2010type malignancy of the tracheobronchial tree, accounting for 0.04%\u20130.2% of primary lung cancers. It may cause severe malignant airway obstruction (SMAO), necessitating urgent intervention. Surgical resection remains the primary treatment, but inoperability or patient preference may require alternative strategies. We report a case of a 57\u2010year\u2010old non\u2010smoking female with PACC\u2010SMAO who presented with total left lung collapse due to left main bronchus (LMB) involvement. She declined surgery and underwent bronchoscopic dual debulking combining electrocautery snaring with repeated intratumoural para\u2010toluenesulfonamide (PTS) injections. The intervention safely reduced tumour burden, restored airway patency, and significantly improved clinical and radiological outcomes without adverse events. Our case underscores PTS as a promising adjunct therapy for inoperable PACC\u2010SMAO, warranting further investigation into its long\u2010term efficacy and optimal dosing. This innovative approach may significantly redefine palliative care options.<\/jats:p>","DOI":"10.1002\/rcr2.70285","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T09:19:16Z","timestamp":1753435156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Central Airway Recanalisation Using Dual Debulking With\u00a0Para\u2010Toluenesulfonamide (<scp>CLEAR<\/scp>\u2010<scp>DUAL<\/scp>\u2010<scp>PTS<\/scp>)"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3149-4328","authenticated-orcid":false,"given":"Chen Yong","family":"Tan","sequence":"first","affiliation":[{"name":"Pulmonology Department Hospital Sultan Idris Shah  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Xin","family":"Tan","sequence":"additional","affiliation":[{"name":"Pulmonology Department Hospital Sultan Idris Shah  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9032-2254","authenticated-orcid":false,"given":"Yen Shen","family":"Wong","sequence":"additional","affiliation":[{"name":"Pulmonology Department Hospital Sultan Idris Shah  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumithra","family":"Appava","sequence":"additional","affiliation":[{"name":"Pulmonology Department Hospital Sultan Idris Shah  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoban Raj","family":"Vasudayan","sequence":"additional","affiliation":[{"name":"Pulmonology Department Hospital Sultan Idris Shah  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriah","family":"Othman","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Sultan Idris Shah  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swee Wei","family":"Leong","sequence":"additional","affiliation":[{"name":"Pulmonology Department Hospital Sultan Idris Shah  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona Zaria","family":"Nasaruddin","sequence":"additional","affiliation":[{"name":"Pulmonology Department Hospital Sultan Idris Shah  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamalul Azizi","family":"Abdul Rahaman","sequence":"additional","affiliation":[{"name":"Pulmonology Department Hospital Sultan Idris Shah  Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.2859"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.232654"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2016.05.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.15289"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.03.70"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:43:06Z","timestamp":1758721386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/rcr2.70285"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70285","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70285"}}