{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:41:23Z","timestamp":1767138083805,"version":"build-2238731810"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pembrolizumab can cause extremely serious skin disorders with high mortality rates, such as Stevens\u2013Johnson syndrome (SJS), with most cases occurring early after immune checkpoint inhibitor treatment. This report describes a patient that developed SJS triggered by methicillin\u2010susceptible\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (MSSA) infection 8\u2009months into pembrolizumab treatment for lung squamous cell carcinoma. A 74\u2010year\u2010old male developed fever, oral mucosal damage, oedematous erythema with erosions predominantly in the trunk and renal dysfunction 8\u2009months after starting pembrolizumab monotherapy for the postoperative recurrence of lung squamous cell carcinoma. SJS was diagnosed and the patient was hospitalised. Cultures of purulent exudates from the facial skin and sputum revealed MSSA. The skin and mucosa findings did not improve despite steroid pulse therapy, but gradual improvements were seen after treatment with ampicillin\u2013sulbactam, vancomycin and four sessions of plasma exchange therapy.\n                  <\/jats:p>","DOI":"10.1002\/rcr2.70290","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T02:54:19Z","timestamp":1753239259000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Stevens\u2013Johnson Syndrome Triggered by Methicillin\u2010Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Infection During Pembrolizumab Treatment for Lung Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Yusuke","family":"Irie","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center  Sakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-2217","authenticated-orcid":false,"given":"Kazutoshi","family":"Isobe","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center  Sakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryogo","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center  Sakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1775-347X","authenticated-orcid":false,"given":"Kensuke","family":"Namba","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center  Sakura 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University Sakura Medical Center  Sakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Murakami","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center  Sakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaichi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center  Sakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Mitsuyama","sequence":"additional","affiliation":[{"name":"Division of Dermatology Medicine, Department of Internal Medicine Toho University Sakura Medical Center  Sakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center  Sakura Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Matsuzawa","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Toho University Sakura Medical Center  Sakura 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