{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:44:48Z","timestamp":1782963888984,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Appendiceal metastasis is a rare complication of primary lung cancer and an extremely rare cause of appendicitis. We present the case of a 62\u2010year\u2010old male who presented with right lower quadrant abdominal pain which revealed not only appendiceal inflammation, but also a lung mass and mediastinal lymph nodes. He then proceeded to appendicectomy and two days post\u2010operatively an endobronchial ultrasound\u2010guided biopsy. His mediastinal lymph node biopsy revealed a lung adenocarcinoma and his subsequent appendiceal immunohistochemistry revealed the same staining pattern for thyroid transcription factor 1 (TTF\u20101) and cytokeratin 7 (CK\u20107). We conducted a literature review which revealed 12 previous case reports of lung metastasis to the appendix causing appendicitis including three patients in whom appendicitis was the presenting complaint leading to lung cancer diagnosis. This case highlights the diversity of presentations for patients suffering from metastatic lung cancer.<\/jats:p>","DOI":"10.1002\/rcr2.703","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:36:59Z","timestamp":1611103019000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lung cancer presenting as an acute appendicitis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9666-9184","authenticated-orcid":false,"given":"Jack","family":"Callum","sequence":"first","affiliation":[{"name":"Respiratory Department Royal North Shore Hospital  Sydney NSW Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Paik","sequence":"additional","affiliation":[{"name":"Respiratory Department Royal North Shore Hospital  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hibbert","sequence":"additional","affiliation":[{"name":"Respiratory Department Royal North Shore Hospital  Sydney NSW Australia"},{"name":"Faculty of Medicine University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"e_1_2_4_2_1","unstructured":"Australian Government Cancer Australia.Lung cancer in Australia statistics.2020.https:\/\/www.canceraustralia.gov.au\/affected-cancer\/cancer-types\/lung-cancer\/statistics(accessed 24 October 2020)."},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6382"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02617258"},{"issue":"8","key":"e_1_2_4_5_1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1177\/000313480407000810","article-title":"Extensive stage small cell lung cancer presenting as an acute perforated appendix: case report and review of the literature","volume":"70","author":"Goldstein EB","year":"2004","journal-title":"Am. 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