{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:05:54Z","timestamp":1773882354331,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Pseudoprogression, a transient radiographic flare caused by immune infiltration, is common after immune\u2010checkpoint inhibitors but has not been reported with tarlatamab, a bispecific T\u2010cell engager approved for third\u2010line small\u2010cell lung cancer (SCLC). A 57\u2010year\u2010old woman with extensive\u2010stage SCLC and syndrome of inappropriate antidiuretic hormone secretion (SIADH) received tarlatamab. Within hours, she developed bone pain; Day 7 imaging showed marked tumour swelling and pleural effusion despite negative cytology and rising serum sodium. Therapy continued. By Day 13, computed tomography demonstrated regression of thoracic and hepatic lesions and falling pro\u2013gastrin\u2010releasing peptide (pro\u2010GRP). Early pseudoprogression and paraneoplastic biomarker improvement may predict efficacy.<\/jats:p>","DOI":"10.1002\/rcr2.70319","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T02:23:11Z","timestamp":1755483791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early Pseudoprogression After Tarlatamab in Small\u2010Cell Lung Cancer: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Yoshio","family":"Nakano","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Sakai City Medical Center  Sakai Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroka","family":"Serizawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sakai City Medical Center  Sakai Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7673-416X","authenticated-orcid":false,"given":"Yuri","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sakai City Medical Center  Sakai Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kuze","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sakai City Medical Center  Sakai Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sakai City Medical Center  Sakai Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwao","family":"Gohma","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Sakai City Medical Center  Sakai Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103531"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S418116"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-024-03833-w"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.284436"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307980"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:51:41Z","timestamp":1756399901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":5,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/rcr2.70319"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70319","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70319"}}