{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T23:40:10Z","timestamp":1758843610264,"version":"3.44.0"},"reference-count":6,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"ABSTRACT<\/jats:title>Endobronchial ultrasound (EBUS)\u2010guided biopsy remains the gold standard in the diagnosis of mediastinal pathologies. However, visualisation of intranodal architecture has yet to be achieved. With the implementation of miniature video probes in interventional pulmonology, these tools may help bring an added dimension to EBUS\u2010guided diagnostics by allowing visualisation of intranodal architecture. We report a four\u2010patient case series demonstrating the clinical use of the Iriscope, a miniature videoprobe, for direct visualisation of mediastinal lymph nodes during EBUS\u2010guided biopsy. In each case, the Iriscope was deployed over a guide\u2010sheath through the working channel of the EBUS bronchoscope following transbronchial needle aspiration (TBNA) and inserted through the biopsy tract into the lymph node under continuous ultrasound guidance. Real\u2010time video imaging allowed inspection of nodal architecture and tissue consistency. The procedure was well tolerated in all cases, and no immediate complications were observed. This novel application introduces a new diagnostic dimension, potentially enhancing interpretation beyond cytologic or histologic sampling. All procedures were technically successful and complication\u2010free, supporting the feasibility and safety of this approach. These findings lay the groundwork for broader clinical validation and integration of direct intranodal endoscopy in interventional pulmonology.<\/jats:p>","DOI":"10.1002\/rcr2.70330","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:30:43Z","timestamp":1757910643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Direct Intranodal Visualization During EBUS<\/scp>\u2010TBNA<\/scp> Using the Iriscope: A Novel Case Series"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5774-074X","authenticated-orcid":false,"given":"Sammy","family":"Onyancha","sequence":"first","affiliation":[{"name":"Department of Pulmonology St. Elisabethen Krankenhaus Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrin","family":"Tekeli","sequence":"additional","affiliation":[{"name":"Department of Pulmonology St. Elisabethen Krankenhaus Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Nitsch","sequence":"additional","affiliation":[{"name":"Department of Pulmonology St. Elisabethen Krankenhaus Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birol","family":"Dedeoglu","sequence":"additional","affiliation":[{"name":"Department of Pulmonology St. Elisabethen Krankenhaus Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel","family":"Havkic","sequence":"additional","affiliation":[{"name":"Department of Pulmonology St. Elisabethen Krankenhaus Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kati","family":"Kiil","sequence":"additional","affiliation":[{"name":"Dr. Senckenbergisches Institut f\u00fcr Pathologie Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Universit\u00e4tsklinikum Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(15)00029\u20106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000001018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000541675"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.14798"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.70057"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/med\u201023\u201065"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T23:09:52Z","timestamp":1758841792000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":6,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/rcr2.70330"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70330","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"type":"print","value":"2051-3380"},{"type":"electronic","value":"2051-3380"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70330"}}