{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:42:19Z","timestamp":1781196139848,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Pulmonary aspergilloma can cause life\u2010threatening haemoptysis. Surgical resection and\/or bronchial artery embolization (BAE) are established treatment modalities, but both can be risky in frail patients with comorbidities. Spontaneous regression of aspergilloma with antifungal agents alone is rare. We report an elderly gentleman with a background history of treated pulmonary tuberculosis, who presented with haemoptysis due to a large left upper lobe aspergilloma. He declined surgery and BAE due to perceived risks. Oral voriconazole and later isavuconazole were prescribed, which led to clinical improvement and significant reduction in the size of the aspergilloma over 6\u2009months. Antifungal agents might be a viable therapeutic option for aspergilloma patients unsuitable or who declined more invasive procedures. Further studies are needed to validate the efficacy and safety of this approach.<\/jats:p>","DOI":"10.1002\/rcr2.70334","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:52:16Z","timestamp":1756360336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful Treatment of Aspergilloma With Antifungal Alone: A Case of Conservative Management"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1592-9119","authenticated-orcid":false,"given":"Ad Rian","family":"Chong","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Melaka Hospital  Melaka Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-1398","authenticated-orcid":false,"given":"Khai Lip","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Melaka Hospital  Melaka Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-4189","authenticated-orcid":false,"given":"Nai\u2010Chien","family":"Huan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Queen Elizabeth Hospital  Kota Kinabalu Sabah Malaysia"},{"name":"Centre for Innovative Pleural Research, Sir Charles Gairdner Hospital  Perth Australia"},{"name":"School of Medical and Health Sciences Edith Cowan University  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Husna","family":"Mohd Aminudin","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Melaka Hospital  Melaka Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja Nor Adilla","family":"Raja Rahaizat","sequence":"additional","affiliation":[{"name":"Department of Radiology Melaka Hospital  Melaka Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasuma","family":"Mohamed Nordin","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Internal Medicine Melaka Hospital  Melaka Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/jof9030381","article-title":"Clinical Manifestations of Human Exposure to Fungi","volume":"9","author":"Oliveira M.","year":"2023","journal-title":"Journal of Fungi (Basel)"},{"issue":"28","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"S3398","DOI":"10.21037\/jtd.2018.08.85","article-title":"Surgical Management of Non\u2010Mycobacterial Fungal Infections","volume":"10","author":"Beamer S.","year":"2018","journal-title":"Journal of Thoracic Disease"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2020.105903","article-title":"Non\u2010Surgical Treatment Options for Pulmonary Aspergilloma","volume":"164","author":"Lang M.","year":"2020","journal-title":"Respiratory Medicine"},{"issue":"4","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"e01337","DOI":"10.1002\/rcr2.1337","article-title":"The Case of Huge Simple Pulmonary Aspergilloma That Responded Remarkably to Drug Therapy","volume":"12","author":"Yokota M.","year":"2024","journal-title":"Respirology Case Reports"},{"issue":"7","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1007\/s00330-020-07533-x","article-title":"The Impact of Bronchial Artery Embolisation on the Quality of Life of Patients With Haemoptysis: A Prospective Observational Study","volume":"31","author":"Omachi N.","year":"2021","journal-title":"European Radiology"},{"issue":"2","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1055\/s-2006-941443","article-title":"Complications of Embolization","volume":"23","author":"Bilbao J. I.","year":"2006","journal-title":"Semin Intervent Radiol"},{"issue":"3","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1128\/microbiolspec.FUNK-0014-2016","article-title":"Fungi That Infect Humans","volume":"5","author":"Kohler J. R.","year":"2017","journal-title":"Microbiology Spectrum"},{"issue":"121","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1183\/09059180.00001011","article-title":"Pulmonary Aspergillosis: A Clinical Review","volume":"20","author":"Kousha M.","year":"2011","journal-title":"European Respiratory Review"},{"key":"e_1_2_9_10_1","first-page":"79","article-title":"Isavuconazole in the Treatment of Invasive Aspergillosis and Mucormycosis Infections","volume":"9","author":"Donnelley M. 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F.","year":"2025","journal-title":"Journal of Infection and Chemotherapy"}],"container-title":["Respirology Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/rcr2.70334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:51:47Z","timestamp":1756399907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/rcr2.70334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/rcr2.70334"],"URL":"https:\/\/doi.org\/10.1002\/rcr2.70334","archive":["Portico"],"relation":{},"ISSN":["2051-3380","2051-3380"],"issn-type":[{"value":"2051-3380","type":"print"},{"value":"2051-3380","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70334"}}