{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:41:47Z","timestamp":1767998507219,"version":"3.49.0"},"reference-count":5,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Respirology Case Reports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report the case of a 41\u2010year\u2010old woman who developed an epithelioid\u2010type pleural mesothelioma (PM) decades after treatment for childhood acute myeloid leukaemia (AML), who was treated with chemotherapy and total body irradiation (TBI). The diagnosis was confirmed by thoracoscopic pleural biopsy and immunohistochemical staining. Although PM is classically associated with asbestos exposure, the patient had no known history of exposure. This case report highlights the fact that PM can occur as a late\u2010onset secondary malignancy following radiation therapy in childhood cancer survivors. Although radiation\u2010induced PM has been reported primarily in survivors of Hodgkin lymphoma or breast cancer, incidences following treatment for leukaemia are exceptionally rare. This case report highlights the importance of considering prior therapeutic irradiation, including total\u2010body irradiation, as a potential etiological factor for non\u2010asbestos\u2010related PM. It also emphasises the need for the long\u2010term surveillance and monitoring of childhood cancer survivors, particularly those who have received radiation therapy.<\/jats:p>","DOI":"10.1002\/rcr2.70342","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T04:23:17Z","timestamp":1758255797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Radiotherapy\u2010Induced Pleural Mesothelioma in a Childhood Leukaemia Survivor: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8217-7763","authenticated-orcid":false,"given":"Sho","family":"Saeki","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Kumamoto Chuo Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rin","family":"Kurosawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kumamoto Chuo Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kumamoto Chuo Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minori","family":"Shimamura","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kumamoto Chuo Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kumamoto Chuo Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kumamoto Chuo Hospital  Kumamoto 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kumamoto University Hospital  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-1127","authenticated-orcid":false,"given":"Takuro","family":"Sakagami","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kumamoto University Hospital  Kumamoto 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